S‐nitrosation and neuronal plasticity

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dc.contributor.authorSantos, A. I.
dc.contributor.authorMartínez Ruiz, Antonio
dc.contributor.authorAraújo, I. M .
dc.date.accessioned2024-04-09T11:43:32Z
dc.date.available2024-04-09T11:43:32Z
dc.date.issued2014-09-05
dc.description.abstractNitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change in response to new stimuli, only in recent years have we begun to understand how NO acts on the molecular and cellular level to orchestrate such important phenomena as synaptic plasticity (modification of the strength of existing synapses) or the formation of new synapses (synaptogenesis) and new neurons (neurogenesis). Post-translational modification of proteins by NO derivatives or reactive nitrogen species is a non-classical mechanism for signalling by NO. S-nitrosation is a reversible post-translational modification of thiol groups (mainly on cysteines) that may result in a change of function of the modified protein. S-nitrosation of key target proteins has emerged as a main regulatory mechanism by which NO can influence several levels of brain plasticity, which are reviewed in this work. Understanding how S-nitrosation contributes to neural plasticity can help us to better understand the physiology of these processes, and to better address pathological changes in plasticity that are involved in the pathophysiology of several neurological diseases.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.refereedTRUE
dc.description.sponsorshipFEDER funds via Programa Operacional Factores de Competitividade (COMPETE)
dc.description.sponsorshipFoundation for Science and Technology (FCT, Portugal)
dc.description.sponsorshipSpanish Government
dc.description.statuspub
dc.identifier.doi10.1111/bph.12827
dc.identifier.issn0007-1188
dc.identifier.issn1476-5381
dc.identifier.officialurlhttps://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.12827
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102882
dc.journal.titleBritish Journal of Pharmacology
dc.language.isoeng
dc.page.final1478
dc.page.initial1468
dc.relation.projectIDSFRH/BD/77903/2011
dc.relation.projectIDPTDC/SAU-OSD/0473/ 2012
dc.relation.projectIDPEst-C/SAU/LA0001/2013–2014
dc.relation.projectIDPEst-OE/EQB/ LA0023/2013–2014
dc.relation.projectIDPS09/00101
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F00875/ES/Modificaciones postraduccionales oxidativas en fisiopatología molecular/
dc.relation.projectIDPRI-AIBPT-2011-1015/E-10/12
dc.rights.accessRightsopen access
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.ucmBioquímica (Farmacia)
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.unesco2302 Bioquímica
dc.titleS‐nitrosation and neuronal plasticity
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number172
dspace.entity.typePublication
relation.isAuthorOfPublicationeec0b303-34c9-47dd-9ec6-704b6c6c7acd
relation.isAuthorOfPublication.latestForDiscoveryeec0b303-34c9-47dd-9ec6-704b6c6c7acd
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