Pore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools

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dc.contributor.authorRivera de la Torre, Esperanza
dc.contributor.authorPalacios Ortega, Juan
dc.contributor.authorGavilanes, José G.
dc.contributor.authorMartínez Del Pozo, Álvaro
dc.contributor.authorGarcía Linares, Sara
dc.date.accessioned2023-06-17T13:26:36Z
dc.date.available2023-06-17T13:26:36Z
dc.date.issued2019
dc.description.abstractAnimal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells. Among PFPs from cnidarians, actinoporins stand out for their small size and molecular simplicity. While native actinoporins require only sphingomyelin for membrane binding, engineered chimeras containing a recognition antibody-derived domain fused to an actinoporin isoform can nonetheless serve as highly specific immunotoxins. Examples of such constructs targeted against malignant cells have been already reported. However, PFPs from arachnid venoms are less well-studied from a structural and functional point of view. Spiders from the Latrodectus genus are professional insect hunters that, as part of their toxic arsenal, produce large PFPs known as latrotoxins. Interestingly, some latrotoxins have been identified as potent and highly-specific insecticides. Given the proteinaceous nature of these toxins, their promising future use as efficient bioinsecticides is discussed throughout this Perspective. Protein engineering and large-scale recombinant production are critical steps for the use of these PFPs as tools to control agriculturally important insect pests. In summary, both families of PFPs, from Cnidaria and Arachnida, appear to be molecules with promising biotechnological applications.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid/Banco de Santander
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/56653
dc.identifier.doi10.3390/toxins11060370
dc.identifier.issn2072-6651
dc.identifier.officialurlhttps://www.mdpi.com/2072-6651/11/6/370/htm
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13494
dc.issue.number6
dc.journal.titleToxins
dc.language.isoeng
dc.page.initial370
dc.publisherMDPI
dc.relation.projectIDPR 75-18-21561
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu577.1
dc.subject.keywordActinoporin
dc.subject.keywordbioinsecticides
dc.subject.keywordimmunotoxin
dc.subject.keywordlatrotoxin
dc.subject.keywordpore-forming proteins
dc.subject.keywordtranscriptomics
dc.subject.keywordvenomics
dc.subject.ucmBioquímica (Química)
dc.titlePore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
relation.isAuthorOfPublication4d35a8a6-8bd3-4ff4-b179-57581d8d36d8
relation.isAuthorOfPublication35824f7f-c79d-4928-9728-21124243bf7a
relation.isAuthorOfPublication.latestForDiscovery35824f7f-c79d-4928-9728-21124243bf7a
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