Biomaterials against Bone Infection.

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dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorGonzález Ortiz, Blanca
dc.contributor.authorIzquierdo Barba, Isabel
dc.date.accessioned2023-06-16T15:17:41Z
dc.date.available2023-06-16T15:17:41Z
dc.date.issued2020-05-26
dc.descriptionRESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID K-4773-2015 (Blanca González Ortiz) ORCID 0000-0002-0493-6071 (Blanca González Ortiz) RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
dc.description.abstractChronic bone infection is considered as one of the most problematic biofilm-related infections. Its recurrent and resistant nature, high morbidity,prolonged hospitalization, and costly medical care expenses have driven the efforts of the scientific community to develop new therapies to improve the standards used today. There is great debate on the management of this kind of infection in order to establish consistent and agreed guidelines in national health systems. The scientific research is oriented toward the design of anti-infective biomaterials both for prevention and cure. The properties of these materials must be adapted to achieve better anti-infective performance and good compatibility, which allow a good integration of the implant with the surrounding tissue. The objective of this review is to study in-depth the antibacterial biomaterials and the strategies underlying them. In this sense, this manuscript focuses on antimicrobial coatings, including the new technological advances on surface modification; scaffolding design including multifunctional scaffolds with both antimicrobial and bone regeneration properties; and nanocarriers based on mesoporous silica nanoparticles with advanced properties (targeting and stimuli-response capabilities).
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Research Council
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/60387
dc.identifier.doi10.1002/adhm.202000310
dc.identifier.issn2192-2640
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/journal/21922659
dc.identifier.relatedurlhttps://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6224
dc.journal.titleAdvanced Healthcare Materials
dc.language.isoeng
dc.publisherWiley Online Library
dc.relation.projectIDERC-2015- AdG (VERDI), Proposal no. 694160
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.keywordBone infection
dc.subject.keywordMesoporous silica nanoparticles
dc.subject.keywordNanocarriers
dc.subject.keywordScaffolds
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.titleBiomaterials against Bone Infection.
dc.typejournal article
dspace.entity.typePublication
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