Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance

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dc.contributor.authorColilla Nieto, Montserrat
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2024-04-04T09:00:18Z
dc.date.available2024-04-04T09:00:18Z
dc.date.issued2023-11
dc.description.abstractBacterial antimicrobial resistance is posed to become a major hazard to global health in the 21st century. An aggravating issue is the stalled antibiotic research pipeline, which requires the development of new therapeutic strategies to combat antibiotic-resistant infections. Nanotechnology has entered into this scenario bringing up the opportunity to use nanocarriers capable of transporting and delivering antimicrobials to the target site, overcoming bacterial resistant barriers. Among them, mesoporous silica nanoparticles (MSNs) are receiving growing attention due to their unique features, including large drug loading capacity, biocompatibility, tunable pore sizes and volumes, and functionalizable silanol-rich surface. This perspective article outlines the recent research advances in the design and development of organically modified MSNs to fight bacterial infections. First, a brief introduction to the different mechanisms of bacterial resistance is presented. Then, we review the recent scientific approaches to engineer multifunctional MSNs conceived as an assembly of inorganic and organic building blocks, against bacterial resistance. These elements include specific ligands to target planktonic bacteria, intracellular bacteria, or bacterial biofilm; stimuli-responsive entities to prevent antimicrobial cargo release before arriving at the target; imaging agents for diagnosis; additional constituents for synergistic combination antimicrobial therapies; and aims to improve the therapeutic outcomes. Finally, this manuscript addresses the current challenges and future perspectives on this hot research area.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Research Council
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.doi10.1021/acs.chemmater.3c02192
dc.identifier.officialurlhttps://doi.org/10.1021/acs.chemmater.3c02192
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102691
dc.issue.number35
dc.journal.titleChemistry of Materials
dc.language.isoeng
dc.page.final8805
dc.page.initial8788
dc.relation.projectIDERC-2015-AdG
dc.relation.projectIDVERDI, Grant No. 694160
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615:54
dc.subject.ucmQuímica
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco23 Química
dc.titleOrganically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublication449a114d-e3bf-4d4c-81c5-2b0c5f050b9d
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery449a114d-e3bf-4d4c-81c5-2b0c5f050b9d
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