An Odorant-Binding Protein as a New Allergen from Siberian Hamster (Phodopus sungorus)

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dc.contributor.authorTorres, J.A.
dc.contributor.authorPastor Vargas, Carlos
dc.contributor.authorde las Heras, M.
dc.contributor.authorVivanco Martínez, Fernando
dc.contributor.authorCuesta, Javier
dc.contributor.authorSastre, J.
dc.date.accessioned2024-07-23T11:12:27Z
dc.date.available2024-07-23T11:12:27Z
dc.date.issued2011-09-07
dc.description.abstractA case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding bands of about 18, 21 and 23 kDa. When the patient's serum was preincubated with rabbit, mouse and gerbil hair extracts, no inhibition of the 3 SH IgE-binding bands was demonstrated. Proteins extracted from the 3 bands were analyzed by N-terminal sequencing and matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry, and peptides were sequenced. IgE-binding bands were identified as being an odorant-binding protein belonging to the lipocalin family. Analysis of the 3 IgE-binding bands found in the hair, urine and salivary glands of SH showed a new allergenic protein lacking cross-reactivity with allergens from other rodents. The 3 bands likely correspond to isoforms of a single allergen.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.fundingtypePagado por el autor
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationTorres JA, Pastor-Vargas C, de las Heras M, Vivanco F, Cuesta J, Sastre J. An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus). Int Arch Allergy Immunol. 2012;157(1):109-12. doi: 10.1159/000324956. Epub 2011 Sep 7. PMID: 21912180.
dc.identifier.doi10.1159/000324956
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.officialurlhttps://karger.com/iaa/article/157/1/109/165603/An-Odorant-Binding-Protein-as-a-New-Allergen-from
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107042
dc.issue.number1
dc.journal.titleInt Arch Allergy Immunol
dc.language.isoeng
dc.page.final112
dc.page.initial109
dc.publisherKarger
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616-056.3
dc.subject.cdu612.017
dc.subject.keywordAnaphylaxis
dc.subject.keywordSiberian hamster
dc.subject.keywordBite
dc.subject.keywordAllergens
dc.subject.keywordLipocalins
dc.subject.keywordOdorant-binding proteins
dc.subject.ucmAlergología
dc.subject.unesco3207.01 Alergias
dc.titleAn Odorant-Binding Protein as a New Allergen from Siberian Hamster (Phodopus sungorus)
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number157
dspace.entity.typePublication
relation.isAuthorOfPublication25af78c7-0077-4891-a14e-bcd8e51fe408
relation.isAuthorOfPublication6f3e7679-cbc7-4f23-8355-2de0876d46ad
relation.isAuthorOfPublication.latestForDiscovery25af78c7-0077-4891-a14e-bcd8e51fe408
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