Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens

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dc.contributor.authorMartínez, Isidoro
dc.contributor.authorOliveros, Juan
dc.contributor.authorCuesta, Isabel
dc.contributor.authorBarrera, Jorge
dc.contributor.authorAusina, Vicente
dc.contributor.authorCasals Carro, María Cristina
dc.contributor.authorLorenzo, Alba de
dc.contributor.authorGarcía, Ernesto
dc.contributor.authorGarcía-Fojeda García-Valdecasas, María Belén
dc.contributor.authorGarmendia, Junkal
dc.contributor.authorGonzález-Nicolau, Mar
dc.contributor.authorLacoma, Alicia
dc.contributor.authorMenéndez, Margarita
dc.contributor.authorMoranta, David
dc.contributor.authorNieto, Amelia
dc.contributor.authorOrtín, Juan
dc.contributor.authorPérez-González, Alicia
dc.contributor.authorPrat, Cristina
dc.contributor.authorRamos-Sevillano, Elisa
dc.contributor.authorRegueiro, Verónica
dc.contributor.authorRodriguez-Frandsen, Ariel
dc.contributor.authorSolís, Dolores
dc.contributor.authorYuste, José
dc.contributor.authorBengoechea, José
dc.contributor.authorMelero, José
dc.date.accessioned2024-01-22T17:28:50Z
dc.date.available2024-01-22T17:28:50Z
dc.date.issued2017
dc.description.abstractLower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipSociedad Española de Neumología y Cirugía Torácica
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationMartínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA and Melero JA (2017) Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front. Microbiol. 8:276. doi: 10.3389/fmicb.2017.00276
dc.identifier.doi10.3389/fmicb.2017.00276
dc.identifier.issn1664-302X
dc.identifier.officialurlhttps://www.doi.org/10.3389/fmicb.2017.00276
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/28298903/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94519
dc.issue.number276
dc.journal.titleFrontiers in Immunology
dc.language.isoeng
dc.publisherFrontiers
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-67033-R/ES/NUEVAS PROTEINAS DE FUSION (F) DEL VIRUS RESPIRATORIO SINCITIAL HUMANO (HRSV) Y DEL METAPNEUMOVIRUS HUMANO (HMPV) CON PROPIEDADES ANTIGENICAS E INMUNOGENICAS MEJORADAS/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2014-57797-R/ES/DETERMINANTES VIRALES Y FACTORES GENETICOS DEL HOSPEDADOR QUE CONTRIBUYEN A LA INFECCION POR EL VIRUS DE LA GRIPE/
dc.relation.projectIDPI15CIII/00024
dc.relation.projectIDSEPAR 054/2011
dc.relation.projectIDSAF2012-39444-C01/02
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-65307-R/ES/FACTORES ANTI-INFECCIOSOS DEL PULMON COMO NUEVAS ESTRATEGIAS TERAPEUTICAS FRENTE A INFECCIONES RESPIRATORIAS/
dc.relation.projectIDSAF2012-39444-C01/02
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2012-39841/ES/ESTRATEGIAS DE KLEBSIELLA PNEUMONIAE PARA SUBVERTIR LOS SISTEMAS DEFENSIVOS DEL HUESPED/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-66520-R/ES/ADAPTACION EVOLUTIVA, PATOGENESIS Y SUBVERSION EUCARIOTA POR HAEMOPHILUS INFLUENZAE EN EL PULMON EPOC: IDENTIFICACION, CARACTERIZACION Y VALORACION DE ESTRATEGIAS TERAPEUTICAS/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2015-70052-R/ES/BUSQUEDA Y DESARROLLO DE NUEVAS APROXIMACIONES PREVENTIVAS Y TERAPEUTICAS FRENTE A LAS INFECCIONES CAUSADAS POR STREPTOCOCCUS PNEUMONIAE/
dc.relation.projectIDPITN-GA-2012-317297
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu577.1
dc.subject.keywordBacterial infections
dc.subject.keywordCore of up-regulated genes
dc.subject.keywordHost response
dc.subject.keywordRespiratory pathogens
dc.subject.keywordViral infections
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco2412 Inmunología
dc.titleApoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublicationd4e23d80-fa5c-4614-bd2d-2c391b596713
relation.isAuthorOfPublication89ed03ac-f011-4290-9a31-7390e12f1724
relation.isAuthorOfPublication.latestForDiscovery89ed03ac-f011-4290-9a31-7390e12f1724
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