Publication:
Differential Metabolic and Transcriptional Responses of Gilthead Seabream (Sparus aurata) Administered with Cortisol or Cortisol-BSA

dc.contributor.authorAedo, Jorge
dc.contributor.authorAravena Canales, Daniela
dc.contributor.authorRuiz Jarabo, Ignacio
dc.contributor.authorOyarzún, Ricardo
dc.contributor.authorMolina, Alfredo
dc.contributor.authorMartínez Rodríguez, Gonzalo
dc.contributor.authorValdés, Juan Antonio
dc.contributor.authorMancera, Juan Miguel
dc.date.accessioned2023-06-16T14:23:40Z
dc.date.available2023-06-16T14:23:40Z
dc.date.issued2021-11-19
dc.description.abstractCortisol is the main glucocorticoid hormone promoting compensatory metabolic responses of stress in teleosts. This hormone acts through genomic and membrane-initiated actions to exert its functions inside the cell. Experimental approaches, using exogenous cortisol administration, confirm the role of this hormone during short (minutes to hours)- and long-term (days to weeks) responses to stress. The role of membrane-initiated cortisol signaling during long-term responses has been recently explored. In this study, Sparus aurata were intraperitoneally injected with coconut oil alone or coconut oil containing cortisol, cortisol-BSA, or BSA. After 3 days of treatment, plasma, liver, and skeletal muscle were extracted. Plasma cortisol, as well as metabolic indicators in the plasma and tissues collected, and metabolism-related gene expression, were measured. Our results showed that artificially increased plasma cortisol levels in S. aurata enhanced plasma glucose and triacylglycerols values as well as hepatic substrate energy mobilization. Additionally, cortisol stimulated hepatic carbohydrates metabolism, as seen by the increased expression of metabolism-related genes. All of these responses, observed in cortisol-administered fish, were not detected by replicating the same protocol and instead using cortisol-BSA, which exclusively induces membrane-initiated effects. Therefore, we suggest that after three days of cortisol administration, only genomic actions are involved in the metabolic responses in S. aurata.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipFondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP)
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/72731
dc.identifier.doi10.3390/ani11113310
dc.identifier.issnElectronic: 2076-2615
dc.identifier.officialurlhttps://doi.org/10.3390/ani11113310
dc.identifier.relatedurlhttps://www.mdpi.com/2076-2615/11/11/3310
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4919
dc.issue.number11
dc.journal.titleAnimals
dc.language.isoeng
dc.page.final15
dc.page.initial1
dc.publisherMDPI
dc.relation.projectID(PID2020- 117557RB-C22); (AGL2016-81808-REDT)
dc.relation.projectID(Grant INCAR 15110027)
dc.relation.projectID(Grant 1201498, Grant 3210050)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu597.5
dc.subject.cdu591.1
dc.subject.cdu577.175.53
dc.subject.keywordCortisol
dc.subject.keywordEnergetic metabolism
dc.subject.keywordFish
dc.subject.keywordGlucocorticoids
dc.subject.keywordSparus aurata
dc.subject.keywordStress response
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmPeces
dc.subject.unesco2401.13 Fisiología Animal
dc.titleDifferential Metabolic and Transcriptional Responses of Gilthead Seabream (Sparus aurata) Administered with Cortisol or Cortisol-BSA
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
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