The Stressed CNS: When Glucocorticoids Aggravate Inflammation

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dc.contributor.authorSorrells, Shawn
dc.contributor.authorCaso Fernández, Javier Rubén
dc.contributor.authorMunhoz, Carolina
dc.contributor.authorSapolsky, Robert
dc.date.accessioned2026-03-26T13:11:10Z
dc.date.available2026-03-26T13:11:10Z
dc.date.issued2009-10-15
dc.description.abstractGlucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differently in different brain regions. In this minireview we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipAdler Foundation
dc.description.statuspub
dc.identifier.citationSorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009). The stressed CNS: when glucocorticoids aggravate inflammation. Neuron, 64(1), 33–39. https://doi.org/10.1016/j.neuron.2009.09.032
dc.identifier.doi10.1016/j.neuron.2009.09.032
dc.identifier.essn1097-4199
dc.identifier.issn0896-6273
dc.identifier.officialurlhttps://doi.org/10.1016/j.neuron.2009.09.032
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0896627309007430?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/134344
dc.issue.number1
dc.journal.titleNeuron
dc.language.isoeng
dc.page.final39
dc.page.initial33
dc.publisherElsevier
dc.rights.accessRightsrestricted access
dc.subject.cdu615.01/.03
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco2490 Neurociencias
dc.subject.unesco2403 Bioquímica
dc.titleThe Stressed CNS: When Glucocorticoids Aggravate Inflammation
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number64
dspace.entity.typePublication
relation.isAuthorOfPublication4b8ce4a4-fb5a-4b64-9a2f-460a47e60741
relation.isAuthorOfPublication.latestForDiscovery4b8ce4a4-fb5a-4b64-9a2f-460a47e60741

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