Gut Microbiota Signatures with Potential Clinical Usefulness in Colorectal and Non-Small Cell Lung Cancers

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dc.contributor.authorTesolato, Sofía
dc.contributor.authorVicente Valor, Juan
dc.contributor.authorPaz Cabezas, Mateo
dc.contributor.authorGómez Garre, Dulcenombre
dc.contributor.authorSánchez González, Silvia
dc.contributor.authorOrtega Hernández, Adriana
dc.contributor.authorDe La-Serna Esteban, Sofía Cristina
dc.contributor.authorDomínguez Serrano, María Inmaculada
dc.contributor.authorDzyakova, Jana
dc.contributor.authorRivera, Daniel
dc.contributor.authorJarabo Sarceda, José Ramón
dc.contributor.authorGómez Martínez, Ana María
dc.contributor.authorHernando Trancho, Florentino
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorIniesta Serrano, María Pilar
dc.contributor.editorRyota Niikura
dc.date.accessioned2024-04-04T06:41:51Z
dc.date.available2024-04-04T06:41:51Z
dc.date.issued2024-03-21
dc.description.abstractThe application of bacterial metagenomic analysis as a biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis of colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). A prospective study was performed on a total of 77 fecal samples from CRC and NSCLC patients and controls. DNA from stool was analyzed for bacterial genomic sequencing using the Ion Torrent™ technology. Bioinformatic analysis was performed using the QIIME2 pipeline. We applied logistic regression to adjust for differences attributable to sex, age, and body mass index, and the diagnostic accuracy of our gut signatures was compared with other previously published results. The feces of patients affected by different tumor types, such as CRC and NSCLC, showed a differential intestinal microbiota profile. After adjusting for confounders, Parvimonas (OR = 53.3), Gemella (OR = 6.01), Eisenbergiella (OR = 5.35), Peptostreptococcus (OR = 9.42), Lactobacillus (OR = 6.72), Salmonella (OR = 5.44), and Fusobacterium (OR = 78.9) remained significantly associated with the risk of CRC. Two genera from the Ruminococcaceae family, DTU089 (OR = 20.1) and an uncharacterized genus (OR = 160.1), were associated with the risk of NSCLC. Our two panels had better diagnostic capacity for CRC (AUC = 0.840) and NSLC (AUC = 0.747) compared to the application of two other published panels to our population. Thus, we propose a gut bacteria panel for each cancer type and show its potential application in cancer diagnosis.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Cirugía
dc.description.departmentDepto. de Fisiología
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad
dc.description.sponsorshipUnión Europea
dc.description.statuspub
dc.identifier.citationTesolato, S.; Vicente-Valor, J.; Paz-Cabezas, M.; Gómez-Garre, D.; Sánchez-González, S.; Ortega-Hernández, A.; de la Serna, S.; Domínguez-Serrano, I.; Dziakova, J.; Rivera, D.; et al. Gut Microbiota Signatures with Potential Clinical Usefulness in Colorectal and Non-Small Cell Lung Cancers. Biomedicines 2024, 12, 703. https://doi.org/10.3390/ biomedicines12030703
dc.identifier.doi10.3390/biomedicines12030703
dc.identifier.issn2227-9059
dc.identifier.officialurlhttps://www.mdpi.com/journal/biomedicines
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102675
dc.issue.number3
dc.journal.titleBiomedicines
dc.language.isoeng
dc.page.initial703
dc.publisherMDPI
dc.relation.projectIDPI19/00073
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616-006.04
dc.subject.keywordmicrobiota
dc.subject.keywordbiomarker
dc.subject.keywordcolorectal cancer
dc.subject.keywordnon-small cell lung cancer
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleGut Microbiota Signatures with Potential Clinical Usefulness in Colorectal and Non-Small Cell Lung Cancers
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
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