OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives
dc.contributor.author | Sánchez-Puebla Fernández, Lidia | |
dc.contributor.author | López Cuenca, Inés | |
dc.contributor.author | García Martín, Elena Salobrar | |
dc.contributor.author | Fernández Albarral, José | |
dc.contributor.author | Matamoros Felipe, José Antonio | |
dc.contributor.author | Elvira Hurtado, Lorena | |
dc.contributor.author | Salazar Corral, Juan José | |
dc.contributor.author | Ramírez Sebastián, José Manuel | |
dc.contributor.author | Hoz Montañana, María Rosa De | |
dc.contributor.author | Ramírez Sebastián, Ana Isabel | |
dc.date.accessioned | 2024-03-05T20:25:16Z | |
dc.date.available | 2024-03-05T20:25:16Z | |
dc.date.issued | 2024-02-27 | |
dc.description.abstract | The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD. | |
dc.description.department | Depto. de Inmunología, Oftalmología y ORL | |
dc.description.department | Unidad Docente de Inmunología, Oftalmología y ORL | |
dc.description.faculty | Fac. de Óptica y Optometría | |
dc.description.faculty | Instituto de Investigaciones Oftalmológicas Ramón Castroviejo | |
dc.description.faculty | Fac. de Medicina | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España | |
dc.description.sponsorship | Universidad Complutense de Madrid (España) | |
dc.description.status | pub | |
dc.identifier.citation | Sánchez-Puebla, L.; López-Cuenca, I.; Salobrar-García, E.; Ramírez, A.I.; Fernández-Albarral, J.A.; Matamoros, J.A.; Elvira-Hurtado, L.; Salazar, J.J.; Ramírez, J.M.; de Hoz, R. OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives. Biomedicines 2024, 12, 528. https://doi.org/10.3390/biomedicines12030528 | |
dc.identifier.doi | 10.3390/biomedicines12030528 | |
dc.identifier.officialurl | https://doi.org/10.3390/biomedicines12030528 | |
dc.identifier.relatedurl | https://www.mdpi.com/2227-9059/12/3/528 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/101985 | |
dc.issue.number | 3 | |
dc.journal.title | Biomedicines | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.relation.projectID | RED2018-102499-T | |
dc.relation.projectID | CT82/20-CT83/20 | |
dc.relation.projectID | CT58/21-CT59/21 | |
dc.rights.accessRights | open access | |
dc.subject.cdu | 617.735-073.75 | |
dc.subject.cdu | 616.894-053.9 | |
dc.subject.cdu | 616-073.75 | |
dc.subject.keyword | Alzheimer’s disease | |
dc.subject.keyword | AD mouse model | |
dc.subject.keyword | Optical coherence tomography | |
dc.subject.keyword | Retina | |
dc.subject.ucm | Oftalmología | |
dc.subject.ucm | Diagnóstico por imagen y medicina nuclear | |
dc.subject.ucm | Neurociencias (Medicina) | |
dc.subject.unesco | 3201.09 Oftalmología | |
dc.subject.unesco | 3205.07 Neurología | |
dc.title | OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 12 | |
dspace.entity.type | Publication | |
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