OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

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dc.contributor.authorSánchez-Puebla Fernández, Lidia
dc.contributor.authorLópez Cuenca, Inés
dc.contributor.authorGarcía Martín, Elena Salobrar
dc.contributor.authorFernández Albarral, José
dc.contributor.authorMatamoros Felipe, José Antonio
dc.contributor.authorElvira Hurtado, Lorena
dc.contributor.authorSalazar Corral, Juan José
dc.contributor.authorRamírez Sebastián, José Manuel
dc.contributor.authorHoz Montañana, María Rosa De
dc.contributor.authorRamírez Sebastián, Ana Isabel
dc.date.accessioned2024-03-05T20:25:16Z
dc.date.available2024-03-05T20:25:16Z
dc.date.issued2024-02-27
dc.description.abstractThe murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.facultyInstituto de Investigaciones Oftalmológicas Ramón Castroviejo
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación de España
dc.description.sponsorshipUniversidad Complutense de Madrid (España)
dc.description.statuspub
dc.identifier.citationSánchez-Puebla, L.; López-Cuenca, I.; Salobrar-García, E.; Ramírez, A.I.; Fernández-Albarral, J.A.; Matamoros, J.A.; Elvira-Hurtado, L.; Salazar, J.J.; Ramírez, J.M.; de Hoz, R. OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives. Biomedicines 2024, 12, 528. https://doi.org/10.3390/biomedicines12030528
dc.identifier.doi10.3390/biomedicines12030528
dc.identifier.officialurlhttps://doi.org/10.3390/biomedicines12030528
dc.identifier.relatedurlhttps://www.mdpi.com/2227-9059/12/3/528
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101985
dc.issue.number3
dc.journal.titleBiomedicines
dc.language.isoeng
dc.publisherMDPI
dc.relation.projectIDRED2018-102499-T
dc.relation.projectIDCT82/20-CT83/20
dc.relation.projectIDCT58/21-CT59/21
dc.rights.accessRightsopen access
dc.subject.cdu617.735-073.75
dc.subject.cdu616.894-053.9
dc.subject.cdu616-073.75
dc.subject.keywordAlzheimer’s disease
dc.subject.keywordAD mouse model
dc.subject.keywordOptical coherence tomography
dc.subject.keywordRetina
dc.subject.ucmOftalmología
dc.subject.ucmDiagnóstico por imagen y medicina nuclear
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco3205.07 Neurología
dc.titleOCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
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