Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration

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dc.contributor.authorPuell Marín, María Cinta
dc.contributor.authorHurtado Ceña, Francisco Javier
dc.contributor.authorPérez Carrasco, María Jesús
dc.contributor.authorContreras Martín, Inés
dc.date.accessioned2023-06-17T08:55:41Z
dc.date.available2023-06-17T08:55:41Z
dc.date.copyright© 2020 SAGE journals.
dc.date.issued2020-11-05
dc.description.abstractPurpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA (p = 0.001). CRT emerged as the only independent predictor of LLD (p = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/63070
dc.identifier.citationPuell Marín, M. C., Hurtado Ceña, F. J., Pérez Carrasco, M. J., Contreras Martín, I. «Association between Central Retinal Thickness and Low Luminance Visual Acuity in Early Age-Related Macular Degeneration». European Journal of Ophthalmology, vol. 31, n.o 5, septiembre de 2021, pp. 2467-73. DOI.org (Crossref), https://doi.org/10.1177/1120672120968740.
dc.identifier.doi10.1177/1120672120968740
dc.identifier.issn1120-6721
dc.identifier.officialurlhttps://doi.org/10.1177%2F1120672120968740
dc.identifier.relatedurlhttps://journals.sagepub.com/doi/abs/10.1177/1120672120968740
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7513
dc.journal.titleEuropean Journal of Ophthalmology
dc.language.isoeng
dc.publisherSage
dc.rights.accessRightsopen access
dc.subject.cdu617.736-053.9
dc.subject.cdu617.735--003.8
dc.subject.cdu617.75
dc.subject.keywordAge-related macular degeneration
dc.subject.keywordCentral retinal thickness
dc.subject.keywordVisual acuity
dc.subject.keywordMesopic vision
dc.subject.keywordLow luminance deficit
dc.subject.keywordRetina
dc.subject.ucmOftalmología
dc.subject.ucmOptometría
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2209.15 Optometría
dc.titleAssociation between central retinal thickness and low luminance visual acuity in early age-related macular degenerationen
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication720db6ca-117d-4df6-9208-aa25c7832cdf
relation.isAuthorOfPublication7791e9b0-678d-49da-9010-8f913d903d58
relation.isAuthorOfPublication.latestForDiscovery720db6ca-117d-4df6-9208-aa25c7832cdf
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