Aspectos Terapéuticos en SARS-CoV-2 (COVID-19)
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2021
Defense date
21/05/2021
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Abstract
Objetivos. Entender el mecanismo de acción del SAR-CoV-2, así como conocer los diferentes tratamientos, sus interacciones farmacológicas y repercusiones psicológicas existentes actualmente.
Material y métodos. Se ha llevado a cabo una búsqueda bibliográfica de referencias publicadas a partir del año 2019, revisiones sistemáticas y ensayos clínicos, los dos tipos de estudios que nos ofrecen una evidencia más robusta, en diferentes bases de datos.
Resultados. A finales de 2019, en la ciudad de Wuhan en China, se identificó un nuevo coronavirus como la causa de los numerosos casos de neumonías que se estaban registrando. La OMS declaró pandemia mundial y designó a la enfermedad el nombre de COVID-19. Aunque no se conoce su verdadero origen se especula que proceda del murciélago. La principal forma de trasmisión del SARS-CoV-2 es entre personas a través de aerosoles o gotitas respiratorias. El proceso infeccioso se produce por la proteína S que reconoce a la ACE2 como su receptor para ingresar en las células alveolares. La neumonía es el síntoma más grave. El periodo de mayor infecciosidad es al comienzo de la enfermedad. Las personas inmunizadas pueden volver a reinfectarse.
Conclusiones. No se conocen el verdadero origen del SARS-CoV-2, transmitiéndose a través de aerosoles, cuyo diagnóstico se lleva a cabo a través de la PCR-real time, siendo las vacunas la única forma de atajo del virus en este momento, aunque la Plitidepsina es un potente fármaco antiviral en desarrollo por una farmacéutica española, que supuestamente reduce la carga viral del SARS-CoV-2 independientemente de la cepa del virus.
Objectives. Understand the mechanism of action of SAR-CoV-2, as well as know the different treatments, their pharmacological interactions and psychological repercussions currently existing. Material and methods. A bibliographic search has been carried out of references published since 2019, systematic reviews and clinical trials, the two types of studies that offer us more robust evidence, in different databases. Results. At the end of 2019, in China's Wuhan city, a new coronavirus was identified as the cause of the many cases of pneumonia being recorded. OMS declared the disease a global pandemic and named the disease COVID-19. Although its true origin is not known, it is speculated that it comes from the bat. The main form of SARS-CoV-2 transmission is between people through aerosols or respiratory droplets. The infectious process is produced by the S protein that recognizes ACE2 as it is receptor to enter alveoolate cells. Pneumonia is the most severe symptom. The period of greatest infectiousness is at the beginning of the disease. Immunized people can re-inject. Conclusions. The true origin of SARS-CoV-2 is not known, transmitting itself through aerosols, the diagnosis of which is carried out through PCR-real time, with vaccines being the only form of a shortcut of the virus at this time, although Plitedepsine is a powerful antiviral drug in development by a Spanish pharmaceutical company, which supposedly reduces the viral load of SARS-CoV-2 regardless of the strain of the virus.
Objectives. Understand the mechanism of action of SAR-CoV-2, as well as know the different treatments, their pharmacological interactions and psychological repercussions currently existing. Material and methods. A bibliographic search has been carried out of references published since 2019, systematic reviews and clinical trials, the two types of studies that offer us more robust evidence, in different databases. Results. At the end of 2019, in China's Wuhan city, a new coronavirus was identified as the cause of the many cases of pneumonia being recorded. OMS declared the disease a global pandemic and named the disease COVID-19. Although its true origin is not known, it is speculated that it comes from the bat. The main form of SARS-CoV-2 transmission is between people through aerosols or respiratory droplets. The infectious process is produced by the S protein that recognizes ACE2 as it is receptor to enter alveoolate cells. Pneumonia is the most severe symptom. The period of greatest infectiousness is at the beginning of the disease. Immunized people can re-inject. Conclusions. The true origin of SARS-CoV-2 is not known, transmitting itself through aerosols, the diagnosis of which is carried out through PCR-real time, with vaccines being the only form of a shortcut of the virus at this time, although Plitedepsine is a powerful antiviral drug in development by a Spanish pharmaceutical company, which supposedly reduces the viral load of SARS-CoV-2 regardless of the strain of the virus.