Phosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk.
dc.contributor.author | Cases, Barbara | |
dc.contributor.author | García-Ara, Carmen | |
dc.contributor.author | Boyano, Maria Teresa | |
dc.contributor.author | Pérez-Gordo, Marina | |
dc.contributor.author | Pedrosa, Maria | |
dc.contributor.author | Vivanco Martínez, Fernando | |
dc.contributor.author | Quirce, Santiago | |
dc.contributor.author | Pastor Vargas, Carlos | |
dc.date.accessioned | 2024-07-08T12:34:24Z | |
dc.date.available | 2024-07-08T12:34:24Z | |
dc.date.issued | 2011-09 | |
dc.description.abstract | This study aimed to characterize the role of phosphorylation of caseins in selective allergy to goat milk (GM) and sheep milk (SM) in patients with good tolerance to cow milk (CM). We performed skin prick tests with milk and caseins from CM, GM, and SM and immunoblotting and specific immunoglobulin (Ig) E determinations with milk and casein from cow and GM and SM. Sensitization to milk and caseins from goat and sheep was demonstrated in all 3 patients by skin tests, determination of specific IgE, or both. Immunoblotting confirmed that GM/SM proteins but not CM proteins were involved in the allergic symptoms. IgE reacted with several protein bands from the caseins and milk extracts of both sheep and goat. Phosphorylation was involved in the different allergenicity of CM caseins. We report the implication of phosphorylation in the allergenicity of caseins involved in selective allergy to GM and SM. | |
dc.description.department | Depto. de Bioquímica y Biología Molecular | |
dc.description.faculty | Fac. de Ciencias Químicas | |
dc.description.fundingtype | Pagado por el autor | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.identifier.citation | Cases B, García-Ara C, Boyano MT, Pérez-Gordo M, Pedrosa M, Vivanco F, Quirce S, Pastor-Vargas C. Phosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk. J Investig Allergol Clin Immunol. 2011;21(5):398-400. PMID: 21905504. | |
dc.identifier.officialurl | https://www.jiaci.org/summary/vol21-issue5-num763 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/105792 | |
dc.issue.number | 5 | |
dc.journal.title | J Investig Allergol Clin Immunol | |
dc.language.iso | eng | |
dc.page.final | 400 | |
dc.page.initial | 398 | |
dc.publisher | Esmon | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.cdu | 616-056.3 | |
dc.subject.keyword | Casein | |
dc.subject.keyword | Cow milk allergy | |
dc.subject.keyword | Food allergens | |
dc.subject.keyword | Phosphorylation. | |
dc.subject.ucm | Alergología | |
dc.subject.unesco | 3207.01 Alergias | |
dc.title | Phosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk. | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 21 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 6f3e7679-cbc7-4f23-8355-2de0876d46ad | |
relation.isAuthorOfPublication | 25af78c7-0077-4891-a14e-bcd8e51fe408 | |
relation.isAuthorOfPublication.latestForDiscovery | 25af78c7-0077-4891-a14e-bcd8e51fe408 |
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