Phosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk.

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dc.contributor.authorCases, Barbara
dc.contributor.authorGarcía-Ara, Carmen
dc.contributor.authorBoyano, Maria Teresa
dc.contributor.authorPérez-Gordo, Marina
dc.contributor.authorPedrosa, Maria
dc.contributor.authorVivanco Martínez, Fernando
dc.contributor.authorQuirce, Santiago
dc.contributor.authorPastor Vargas, Carlos
dc.date.accessioned2024-07-08T12:34:24Z
dc.date.available2024-07-08T12:34:24Z
dc.date.issued2011-09
dc.description.abstractThis study aimed to characterize the role of phosphorylation of caseins in selective allergy to goat milk (GM) and sheep milk (SM) in patients with good tolerance to cow milk (CM). We performed skin prick tests with milk and caseins from CM, GM, and SM and immunoblotting and specific immunoglobulin (Ig) E determinations with milk and casein from cow and GM and SM. Sensitization to milk and caseins from goat and sheep was demonstrated in all 3 patients by skin tests, determination of specific IgE, or both. Immunoblotting confirmed that GM/SM proteins but not CM proteins were involved in the allergic symptoms. IgE reacted with several protein bands from the caseins and milk extracts of both sheep and goat. Phosphorylation was involved in the different allergenicity of CM caseins. We report the implication of phosphorylation in the allergenicity of caseins involved in selective allergy to GM and SM.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.fundingtypePagado por el autor
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCases B, García-Ara C, Boyano MT, Pérez-Gordo M, Pedrosa M, Vivanco F, Quirce S, Pastor-Vargas C. Phosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk. J Investig Allergol Clin Immunol. 2011;21(5):398-400. PMID: 21905504.
dc.identifier.officialurlhttps://www.jiaci.org/summary/vol21-issue5-num763
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105792
dc.issue.number5
dc.journal.titleJ Investig Allergol Clin Immunol
dc.language.isoeng
dc.page.final400
dc.page.initial398
dc.publisherEsmon
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616-056.3
dc.subject.keywordCasein
dc.subject.keywordCow milk allergy
dc.subject.keywordFood allergens
dc.subject.keywordPhosphorylation.
dc.subject.ucmAlergología
dc.subject.unesco3207.01 Alergias
dc.titlePhosphorylation reduces the allergenicity of cow casein in children with selective allergy to goat and sheep milk.
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number21
dspace.entity.typePublication
relation.isAuthorOfPublication6f3e7679-cbc7-4f23-8355-2de0876d46ad
relation.isAuthorOfPublication25af78c7-0077-4891-a14e-bcd8e51fe408
relation.isAuthorOfPublication.latestForDiscovery25af78c7-0077-4891-a14e-bcd8e51fe408
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