Cellular and molecular bases of neuroplasticity: brainstem effects after cochlear damage

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dc.contributor.authorGil Loyzaga, Pablo
dc.contributor.authorCarricondo Orejana, Francisco Javier
dc.contributor.authorBartolomé Pascual, María Visitación
dc.contributor.authorIglesias Moreno, María Cruz
dc.contributor.authorRodríguez Gómez, Fernando Luis
dc.contributor.authorPoch Broto, Joaquín
dc.date.accessioned2024-01-18T08:26:52Z
dc.date.available2024-01-18T08:26:52Z
dc.date.issued2010-02-15
dc.description.abstractAfter a cochlear lesion or auditory nerve damage, afferent connections from auditory ganglia can be highly altered. This results in a clear reduction of auditory input and an alteration of connectivity of terminals on cochlear nuclei neurons. Such a process could stimulate the reorganization of the neural circuits and neuroplasticity. Cochlea removal has been demonstrated to be a good model in which to analyse brainstem neuroplasticity, particularly with regard to the cochlear nuclei. After cochlea removal three main periods of degeneration and regeneration were observed. Early effects, during the first week post lesion, involved acute degeneration with nerve ending oedema and degeneration. During the second and, probably, the third post lesion weeks, degeneration was still present, even though a limited and diffuse expression of GAP-43 started. Around 1 month post lesion, degeneration at the cochlear nuclei progressively disappeared and a relevant GAP-43 expression was found. We conclude that neuroplasticity leads neurons to modify their activity and/or their synaptic tree as a consequence of animal adaptation to learning and memory. For the human being neuroplasticity is involved in language learning and comprehension, particularly the acquisition of a second language. Neuroplasticity is important for therapeutic strategies, such as hearing aids and cochlear implants.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationGil-Loyzaga, P., Carricondo, F., Bartolomé, M. V., Iglesias, M. C., Rodríguez, F., & Poch-Broto, J. (2010). Cellular and molecular bases of neuroplasticity: brainstem effects after cochlear damage. Acta oto-laryngologica, 130(3), 318–325. https://doi.org/10.1080/00016480903127468
dc.identifier.doi10.3109/00016480903127468
dc.identifier.essn1651-2251
dc.identifier.issn0001-6489
dc.identifier.officialurlhttps://www.tandfonline.com/doi/full/10.3109/00016480903127468
dc.identifier.pmid19593683
dc.identifier.relatedurlhttps://www.tandfonline.com/journals/ioto20
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93745
dc.issue.number3
dc.journal.titleActa Oto-Laryngologica
dc.language.isoeng
dc.page.final325
dc.page.initial318
dc.publisherTaylor and Francis Group
dc.rights.accessRightsopen access
dc.subject.cdu616.21
dc.subject.keywordNeuroplasticity
dc.subject.keywordcochlea
dc.subject.keywordbrainstem
dc.subject.keywordcochlear nuclei
dc.subject.keywordauditory system
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.ucmBiología celular (Biología)
dc.subject.ucmOtorrinolaringología
dc.subject.unesco2411.13 Fisiología de la Audición
dc.subject.unesco2407 Biología Celular
dc.subject.unesco3213.05 Cirugía de Garganta, Nariz y Oídos
dc.titleCellular and molecular bases of neuroplasticity: brainstem effects after cochlear damage
dc.typejournal article
dc.type.hasVersionCVoR
dc.volume.number130
dspace.entity.typePublication
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