Publication:
The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan

dc.contributor.authorGarrido Tarrio, Antonio
dc.contributor.authorCruces, Julia
dc.contributor.authorCeprián, Noemí
dc.contributor.authorDíaz del Cerro, E.
dc.contributor.authorFélix, J.
dc.contributor.authorFuente del Rey, Mónica de la
dc.date.accessioned2023-06-16T15:18:49Z
dc.date.available2023-06-16T15:18:49Z
dc.date.issued2020-04-10
dc.description.abstractAdult prematurely aging mice (PAM) show behavioral deterioration, premature immunosenescence and increased oxidative stress, impairments that are associated with their shorter lifespan, compared to the corresponding exceptional non-prematurely aging mice (ENPAM). When PAM live in a predominantly ENPAM environment (2/5, respectively) they exhibit an improvement of immunity and redox state in their spleen and thymus leukocytes, and an increased lifespan. Nevertheless, it is unknown if other PAM/ENPAM ratios could affect behavioral and peritoneal leukocyte functions of PAM and change their lifespan. ENPAM and PAM were divided into the following groups: C-ENPAM (8 ENPAM in the cage); C-PAM (8 PAM in the cage); ENPAM > 50% and PAM < 50% (5 ENPAM/2 PAM in each cage); ENPAM = 50% and PAM = 50% (4 ENPAM/ 4 PAM in each cage), and PAM > 50% and ENPAM < 50% (5 PAM/2 ENPAM in each cage). After two months, mice were submitted to a battery of behavioral tests. Several functions and oxidative stress parameters were then assessed in their peritoneal leukocytes. Animals were maintained in these conditions to analyze their lifespan. The results showed that PAM > 50%, PAM = 50% and PAM < 50% exhibited better behavioral responses, immunity and redox states in their peritoneal leukocytes than C-PAM. This improvement was higher when the number of ENPAM in the cage was increased, with most of the parameters in PAM < 50% reaching similar values to those in C-ENPAM, and an increased lifespan. However, ENPAM that cohabited with PAM showed, in general, an impairment of parameters studied. In conclusion, the PAM/ENPAM cohabitation ratio is relevant to behavior and immunity
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/Fondo Europeo de Desarrollo Regional(FEDER)
dc.description.sponsorshipUniversidad Complutense de Madrid (UCM)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/60825
dc.identifier.doi10.1016/j.jneuroim.2020.577240
dc.identifier.issn0165-5728, ESSN: 1872-8421
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/abs/pii/S0165572820300023
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6307
dc.issue.number577240
dc.journal.titleJournal of Neuroimmunology
dc.language.isoeng
dc.page.final17
dc.page.initial1
dc.publisherElsevier
dc.relation.projectID(PI15/01787)
dc.relation.projectID(910379)
dc.rights.accessRightsrestricted access
dc.subject.cdu612.67
dc.subject.cdu591.1
dc.subject.keywordSocial environmental
dc.subject.keywordStrategy prematurely
dc.subject.keywordAging Mice Behavior
dc.subject.keywordImmunity
dc.subject.keywordMean lifespan
dc.subject.ucmInmunología
dc.subject.ucmFisiología animal (Biología)
dc.subject.unesco2412 Inmunología
dc.subject.unesco2401.13 Fisiología Animal
dc.titleThe ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan
dc.typejournal article
dc.volume.number343
dspace.entity.typePublication
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