Clinical evaluation of the sedative, antinociceptive and cardiorespiratory effects of intranasal dexmedetomidine combined with methadone in healthy dogs
dc.contributor.author | Bustamante Domínguez, Rocío | |
dc.contributor.author | Gómez de Segura IA | |
dc.contributor.author | Canfrán Arrabe, Susana | |
dc.date.accessioned | 2024-01-30T15:41:11Z | |
dc.date.available | 2024-01-30T15:41:11Z | |
dc.date.issued | 2024-01-17 | |
dc.description.abstract | In this prospective, randomised, blinded clinical study, we compared the sedative, antinociceptive and cardiorespiratory effects of intranasal (IN) dexmedetomidine at 5 μg/kg (diluted with 0.03 mL/kg NaCl 0.9%, DEX) with or without methadone (0.3 mg/kg; DEXMET), through a mucosal atomization device to one nostril in twenty healthy client-owned dogs. At 5-min intervals over 45 min, sedation score, onset, cardiopulmonary variables, mechanical nociceptive thresholds (MNTs) were assessed, also ease of administration, adverse effects, and response to IV catheterization. Statistical analysis employed t-test, the Mann-Whitney U, repeated measures ANOVA and Chi-square tests as appropriate (P < 0.05). Higher sedation ocurred in DEXMET (7 [5–10]) compared to DEX (5 [2–7]) from 15 to 30 min (P < 0.01, median [interquartile range]). Heart rate was lower in DEXMET (P < 0.01; 65% reduction vs. 41% in DEX, P = 0.001). The MNTs were higher in DEXMET than DEX from 15 to 45 min (P < 0.01), peaking at T30 (17.1 ± 3.8, DEXMET and 8.5 ± 5.4 N, DEX). No differences were observed in mean arterial blood pressure and respiratory rate. Intranasal administration was considered easy for 8 dogs per group. Reverse sneezing (8 dogs; P < 0.001), sialorrhea and retching (4 and 2 dogs, respectively) occurred in DEXMET. Response to catheterisation was lower in DEXMET than DEX (P = 0.039; 2 and 7 dogs, respectively). In conclusion, intranasal methadone (0.3 mg/kg) increased the sedative and antinociceptive effects produced by dexmedetomidine (5 μg/kg) in healthy dogs and resulted in lower heart rate. | |
dc.description.department | Depto. de Medicina y Cirugía Animal | |
dc.description.faculty | Fac. de Veterinaria | |
dc.description.refereed | TRUE | |
dc.description.status | inpress | |
dc.identifier.citation | Bustamante, R., Canfrán, S., & de Segura, I. G. (2024). Clinical evaluation of the sedative, antinociceptive and cardiorespiratory effects of intranasal dexmedetomidine combined with methadone in healthy dogs. The Veterinary Journal, 106065. | |
dc.identifier.doi | https://doi.org/10.1016/j.tvjl.2024.106065 | |
dc.identifier.essn | 1532-2971 | |
dc.identifier.issn | 1090-0233 | |
dc.identifier.officialurl | https://www.sciencedirect.com/science/article/pii/S1090023324000042?via%3Dihub | |
dc.identifier.pmid | 38228282 | |
dc.identifier.relatedurl | https://pubmed.ncbi.nlm.nih.gov/38228282/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/96656 | |
dc.journal.title | The Veterinary Journal | |
dc.language.iso | eng | |
dc.rights | Attribution 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.keyword | Dexmedetomidine | |
dc.subject.keyword | Dog | |
dc.subject.keyword | Intranasal | |
dc.subject.keyword | Sedation | |
dc.subject.keyword | Methadone | |
dc.subject.ucm | Ciencias Biomédicas | |
dc.subject.ucm | Veterinaria | |
dc.subject.unesco | 32 Ciencias Médicas | |
dc.title | Clinical evaluation of the sedative, antinociceptive and cardiorespiratory effects of intranasal dexmedetomidine combined with methadone in healthy dogs | |
dc.type | journal article | |
dc.volume.number | 303 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 84973b2f-f9b6-4b64-9c2f-de41fb4456d6 | |
relation.isAuthorOfPublication | 7ff65a29-c589-4d52-83b6-e419e24c7b09 | |
relation.isAuthorOfPublication.latestForDiscovery | 7ff65a29-c589-4d52-83b6-e419e24c7b09 |
Download
Original bundle
1 - 1 of 1
Loading...
- Name:
- 2024_Intranasal Study_The Veterinary Journal.pdf
- Size:
- 982.36 KB
- Format:
- Adobe Portable Document Format