Optomagnetic nanofluids for controlled brain hyperthermia: a critical study

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dc.contributor.authorMéndez González, Diego
dc.contributor.authorLifante, José
dc.contributor.authorZabala Gutiérrez, Irene
dc.contributor.authorMarin, Riccardo
dc.contributor.authorXimendes, Erving
dc.contributor.authorSanz-de Diego, Elena
dc.contributor.authorIglesias-de la Cruz, M. Carmen
dc.contributor.authorTeran, Francisco J.
dc.contributor.authorRubio Retama, Benito Jorge
dc.contributor.authorJaque, Daniel
dc.date.accessioned2024-02-12T09:45:17Z
dc.date.available2024-02-12T09:45:17Z
dc.date.issued2022-10-16
dc.description.abstractOptomagnetic nanofluids (OMNFs) are colloidal dispersions of nanoparticles (NPs) with combined magnetic and optical properties. They are especially appealing in biomedicine since they can be used as minimally invasive platforms for controlled hyperthermia treatment of otherwise difficultly accessible tumors such as intracranial ones. On the one hand, magnetic NPs act as heating mediators when subjected to alternating magnetic fields or light irradiation. On the other hand, suitably tailored luminescent NPs can provide a precise and remote thermal readout in real time. The combination of heating and thermometric properties allows, in principle, to precisely monitor the increase in the temperature of brain tumors up to the therapeutic level, without causing undesired collateral damage. In this work we demonstrate that this view is an oversimplification since it ignores the presence of relevant interactions between magnetic (γ-Fe2O3 nanoflowers) and luminescent nanoparticles (Ag2S NPs) that result in a detrimental alteration of their physicochemical properties. The magnitude of such interactions depends on the interparticle distance and on the surface properties of nanoparticles. Experiments performed in mouse brains (phantoms and ex vivo) revealed that OMNFs cannot induce relevant heating under alternating magnetic fields and fail to provide reliable temperature reading. In contrast, we demonstrate that the use of luminescent nanofluids (containing only Ag2S NPs acting as both photothermal agents and nanothermometers) stands out as a better alternative for thermally monitored hyperthermia treatment of brain tumors in small animal models.eng
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipInstituto Ramón y Cajal de Investigación Sanitaria
dc.description.statuspub
dc.identifier.citationMendez-Gonzalez D, Lifante J, Zabala Gutierrez I, Marin R, Ximendes E, Sanz-de Diego E, et al. Optomagnetic nanofluids for controlled brain hyperthermia: a critical study. Nanoscale 2022;14:16208–19. https://doi.org/10.1039/D2NR03413A.
dc.identifier.doi10.1039/D2NR03413A
dc.identifier.essn2040-3372
dc.identifier.issn2040-3364
dc.identifier.officialurlhttps://doi.org/10.1039/D2NR03413A
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101176
dc.journal.titleNanoscale
dc.language.isoeng
dc.page.final16219
dc.page.initial16208
dc.publisherROYAL SOCIETY OF CHEMISTRY. THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
dc.relation.projectIDinfo:eu-repo/grantAgreement/P2022/BMD7403 RENIM-CM
dc.relation.projectIDinfo:eu-repo/grantAgreement/NANOMAGCOST/P2018/NMT-4321
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PID2021-123318-OB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2017-85617-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/SEV-2016-0686
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PID2019-106211RB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/HIPERNANO/RED2018–102626–T
dc.relation.projectIDinfo:eu-repo/grantAgreement/PR38/21-36
dc.relation.projectIDinfo:eu-repo/grantAgreement/801305
dc.rights.accessRightsrestricted access
dc.subject.cdu615:54
dc.subject.cdu615.31
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmQuímica
dc.subject.unesco23 Química
dc.titleOptomagnetic nanofluids for controlled brain hyperthermia: a critical study
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number14
dspace.entity.typePublication
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relation.isAuthorOfPublication24f8ceb9-f02a-41ac-851f-5182f31d41a4
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relation.isAuthorOfPublication.latestForDiscoveryb7cbb23c-2419-4694-9478-22cbcc2a3e69
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