Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Simple item page
dc.contributor.authorArcos Navarrete, Daniel
dc.contributor.authorPortolés Pérez, María Teresa
dc.date.accessioned2024-02-22T13:20:47Z
dc.date.available2024-02-22T13:20:47Z
dc.date.issued2023-01-21
dc.description.abstractResearch in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (FEDER)
dc.description.sponsorshipAgencia Estatal de Investigación (AEI)
dc.description.sponsorshipMinisterio de Ciencia e Innovación
dc.description.statuspub
dc.identifier.doi10.3390/ijms24043249
dc.identifier.essn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101671
dc.issue.number24
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial3249
dc.relation.projectIDMAT2016-75611-R AEI/FEDER
dc.relation.projectIDPID2020-11709RB-I00
dc.rights.accessRightsopen access
dc.subject.cdu615:54
dc.subject.cdu615.31
dc.subject.keywordMesoporous nanoparticles
dc.subject.keywordBioactivity
dc.subject.keywordBone regeneration
dc.subject.keywordDrug delivery
dc.subject.keywordTherapeutic ions
dc.subject.keywordCellular response
dc.subject.keywordIn vivo studies
dc.subject.ucmQuímica
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco23 Química
dc.titleMesoporous Bioactive Nanoparticles for Bone Tissue Applications
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublicationd92c7075-3d31-45ec-a18d-35a5010ee8e1
relation.isAuthorOfPublication4b317058-0bd1-4fd8-afab-5fa79a4b7002
relation.isAuthorOfPublication.latestForDiscoveryd92c7075-3d31-45ec-a18d-35a5010ee8e1
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
119. Int J Mol Sci 2023, 24, 3249.pdf
Size:
2.54 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos