Publication:
Craniofacial characteristics in Van der Woude syndrome

dc.contributor.authorEstévez Arroyo, Blanca
dc.contributor.authorGómez Mendo, Ignacio
dc.contributor.authorRomero Maroto, Martín
dc.contributor.authorSolano Reina, Enrique
dc.contributor.authorIglesias Linares, Alejandro
dc.date.accessioned2023-06-22T10:55:08Z
dc.date.available2023-06-22T10:55:08Z
dc.date.issued2022-03-14
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractAim: To describe the particular craniofacial characteristics of Van der Woude syndrome(VWS) patients compared to patients with a non-syndromic cleft (CG1) and to a malocclusive healthy population (CG2). Material and methods: Retrospective case-control study. A sample of 110 matchedpatients was recruited (VWS (n = 7), CG1 (n = 49), CG2 (n = 49)). Subsequently, 37 radiometric variables were analysed and the dental-skeletal ages were determined. The intra/inter-observer method errors were quantified. Descriptive statistics were computed, and different inferential analysis tests were used depending on the normality of the data (Chi-square test, Fisher's exact test, paired Student's T-test, Mann–Whitney U test) (p-value < 0.05). Pairwise comparisons were corrected by Bonferroni's criteria. Results: VW-patients presented specific craniofacial characteristics and morphology. A marked tendency to the vertical growth pattern was found in VW-patients compared to CG1-CG2 (p < 0.001); at the sagittal level, skeletal class II caused by mandibular retrognathism, with a greatly increased ANB angle compared to CG1 (p = 0.042). Dental analysis showed that the lower incisor was more retruded and retroclined (p < 0.05 in all cases) and the interincisal angulation was increased (p < 0.001 (CG2)). At the profile level, an open nasolabial angle (p = 0.040; CG1) and a more protruding lower lip with respect to the Sn-Pg plane (p = 0.040 (CG1); p = 0.044 (CG2)) were observed. Conclusions: VW-patients present particular characteristics in the facial skeletal structures. There is a critical necessity to increase the evidence regarding specific clinical features and orofacial pathology of rare diseases such as VWS, which will help to these minorities to gain access in the future to a better quality of care with precise treatment and diagnostic necessities.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74116
dc.identifier.doi10.1111/odi.14187
dc.identifier.issn1354-523X
dc.identifier.officialurlhttps://doi.org/10.1111/odi.14187
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71886
dc.journal.titleOral Diseases
dc.language.isoeng
dc.publisherWiley
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.keywordcraniofacial
dc.subject.keyworddental diseases
dc.subject.keyworddiagnostics
dc.subject.ucmOdontología (Odontología)
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.titleCraniofacial characteristics in Van der Woude syndrome
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication3e0a8d8c-31d3-4e60-8499-357c2b5cee06
relation.isAuthorOfPublication.latestForDiscovery3e0a8d8c-31d3-4e60-8499-357c2b5cee06
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