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SatR is a repressor of fluoroquinolone efflux pump SatAB

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dc.contributor.authorSan Millán, Álvaro
dc.contributor.authorMontero Serra, Natalia
dc.contributor.authorGutiérrez, Belén
dc.contributor.authorMartínez Ovejero, Cristina
dc.contributor.authorCarrilero Aguado, Laura
dc.contributor.authorGonzález Zorn, Bruno
dc.contributor.authorEscudero García-Calderón, José Antonio
dc.date.accessioned2023-06-19T15:05:03Z
dc.date.available2023-06-19T15:05:03Z
dc.date.issued2013-07
dc.description.abstractStreptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39657
dc.identifier.doi10.1128/AAC.00515-13
dc.identifier.issn1098-6596
dc.identifier.officialurlhttp://dx.doi.org/10.1128 /AAC.00515-13
dc.identifier.urihttps://hdl.handle.net/20.500.14352/35295
dc.issue.number7
dc.journal.titleAntimicrobial agents and chemotherapy
dc.language.isoeng
dc.page.final3
dc.page.initial3430
dc.publisherAmerican Society for Microbiology
dc.relation.projectIDEVOTAR (282004)
dc.relation.projectIDBIO 2010-20204
dc.relation.projectIDPRI-PIBIN-2011-0915
dc.relation.projectIDVIGILANCIA SANITARIA-CM (S2009/AGR-1489)
dc.rights.accessRightsrestricted access
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleSatR is a repressor of fluoroquinolone efflux pump SatAB
dc.typejournal article
dc.volume.number57
dspace.entity.typePublication
relation.isAuthorOfPublication226746a8-2306-4c65-b577-0e87145953c2
relation.isAuthorOfPublicationabbfe61a-3e58-4cfb-85fc-d2e2ec46b0a3
relation.isAuthorOfPublicationf2840ea1-2146-4244-babd-79c986a18986
relation.isAuthorOfPublication.latestForDiscovery226746a8-2306-4c65-b577-0e87145953c2

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