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The osteocyte: A multifunctional cell within the bone

dc.contributor.authorTorres García Denche, Jesús
dc.contributor.authorLópez-Quiles Martínez, Juan
dc.contributor.authorHernández Vallejo, Gonzalo
dc.contributor.authorVega, Jose Antonio
dc.contributor.authorFernández-Tresguerres Hernández-Gil, Isabel
dc.date.accessioned2024-01-11T18:23:20Z
dc.date.available2024-01-11T18:23:20Z
dc.date.issued2020
dc.description.abstractThe knowledge of bone biology has largely changed in the last few decades. Osteocytes are multifunc- tional bone cells that are surrounded by mineralized bone matrix and for decades it was considered that they might be relatively inactive cells. However, nowadays it is known that osteocytes are highly active cells which are indispensable for the normal function of the skeleton, playing main roles in several physiological processes, both within and beyond the bone microenvironment. This review highlights and updates the current state of knowledge of the osteocyte and focuses on its roles in bone remodeling and mineral homeostasis, and also reviews its recently discovered endocrine function. Osteocytes secrete sclerostin (a protein that works as a negative regulator of bone mass), and FGF-23, the most important osteocyte-secreted endocrine factor, since it is able to regulate the phosphate metabolism. Moreover, osteocytes can act as mechanosensory cells, transforming the mechanical strain into chemical signal- ing towards the effector cells (osteoblasts and osteoclasts). Therefore, the osteocyte plays an important role in bone biology, specifically in the remodeling process, since it regulates both the osteoblast and osteoclast activity. Finally, the paper discusses the clinical application of the bone biology, updating the new therapies against bone-loss disorders.en
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationTresguerres FGF, Torres J, López-Quiles J, Hernández G, Vega JA, Tresguerres IF. The osteocyte: A multifunctional cell within the bone. Annals of Anatomy - Anatomischer Anzeiger [Internet]. 1 de enero de 2020 [citado 11 de enero de 2024];227:151422. Disponible en: https://www.sciencedirect.com/science/article/pii/S0940960219301268.
dc.identifier.doi10.1016/j.aanat.2019.151422
dc.identifier.issn1618-0402
dc.identifier.officialurlhttps://www.doi.org/10.1016/j.aanat.2019.151422
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92640
dc.journal.titleAnnals of anatomy
dc.language.isoeng
dc.page.initial151422
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu611.71
dc.subject.keywordOsteocyte
dc.subject.keywordBone remodeling
dc.subject.keywordSclerostin
dc.subject.keywordFGF-23
dc.subject.ucmOdontología (Odontología)
dc.subject.unesco2410 Biología Humana
dc.titleThe osteocyte: A multifunctional cell within the boneen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number230
dspace.entity.typePublication
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