Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides

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dc.contributor.authorSridharan, Vellaisamy
dc.contributor.authorMenéndez Ramos, José Carlos
dc.contributor.authorRuiz Serrano, Miriam
dc.date.accessioned2025-12-15T14:11:02Z
dc.date.available2025-12-15T14:11:02Z
dc.date.issued2009
dc.description.abstractIn the presence of sodium acetate, the reaction between 2,2,6-trimethyl-4H-1,3-dioxin-4-one and secondary or tertiary alcohols (including chiral ones) or primary or secondary amines could be carried out in refluxing tetrahydrofuran, under much milder conditions than those described in the literature. In these new conditions, side products normally observed using the traditional protocol were avoided, and b-keto esters and b-ketoamides were normally obtained in quantitative yields
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationSridharan V, Ruiz M, Menéndez J. Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides. Synthesis 2010;2010:1053–7. https://doi.org/10.1055/s-0029-1217135.
dc.identifier.doi10.1055/s-0029-1217135
dc.identifier.essn1437-210X
dc.identifier.issn0039-7881
dc.identifier.officialurlhttps://dx.doi.org/10.1055/s-0029-1217135
dc.identifier.urihttps://hdl.handle.net/20.500.14352/129002
dc.journal.titleSynthesis: Journal of Synthetic Organic Chemistry
dc.language.isoeng
dc.page.final1057
dc.page.initial1053
dc.publisherThieme Gruppe
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC//CTQ2006-10930/ES/NUEVAS REACCIONES MULTICOMPONENTE CATALIZADAS POR ESPECIES DE CERIO (IV): APLICACIONES EN LA GENERACION DE DIVERSIDAD Y COMPLEJIDAD MOLECULAR/
dc.relation.projectIDinfo:eu-repo/grantAgreement/UCM-CAM//920234
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu547
dc.subject.keywordAcetoacetylation
dc.subject.keywordChiral auxiliaries
dc.subject.keywordDicarbonyl compounds
dc.subject.keywordEsters
dc.subject.keywordAmides
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2306 Química Orgánica
dc.titleMild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number6
dspace.entity.typePublication
relation.isAuthorOfPublication4c8ca147-677d-4846-97b7-d4419662ff60
relation.isAuthorOfPublication4db1d8a4-04dc-4408-a692-c08b5281a87a
relation.isAuthorOfPublication.latestForDiscovery4c8ca147-677d-4846-97b7-d4419662ff60

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