Targeting strategies for improving the efficacy of nanomedicine in oncology

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dc.contributor.authorVillaverde Cantizano, Gonzalo
dc.contributor.authorBaeza García, Alejandro
dc.date.accessioned2024-02-02T17:24:06Z
dc.date.available2024-02-02T17:24:06Z
dc.date.issued2019
dc.description.abstractThe use of nanoparticles as drug carriers has provided a powerful weapon in the fight against cancer. These nanocarriers are able to transport drugs that exhibit very different nature such as lipophilic or hydrophilic drugs and big macromolecules as proteins or RNA. Moreover, the external surface of these carriers can be decorated with different moieties with high affinity for specific membrane receptors of the tumoral cells to direct their action specifically to the malignant cells. The selectivity improvement yielded by these nanocarriers provided a significative enhancement in the efficacy of the transported drug, while the apparition of side effects in the host was reduced. Additionally, it is possible to incorporate targeting moieties selective for organelles of the cell, which improves even more the effect of the transported agents. In the last years, more sophisticated strategies such as the use of switchable, hierarchical or double targeting strategies have been proposed for overcoming some of the limitations of conventional targeting strategies. In this review, recent advances in the development of targeted nanoparticles will be described with the aim to present the current state of the art of this technology and its huge potential in the oncological field.eng
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Educación y Ciencia (España)
dc.description.statuspub
dc.identifier.doi10.3762/bjnano.10.16
dc.identifier.issn2190-4286
dc.identifier.officialurlhttps://doi.org/10.3762/bjnano.10.16
dc.identifier.relatedurlhttps://www.beilstein-journals.org/bjnano/articles/10/16
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98465
dc.language.isoeng
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordAntitumoral therapy
dc.subject.keywordNanomedicine
dc.subject.keywordSmart nanocarriers
dc.subject.keywordTargeted nanoparticles
dc.subject.ucmCiencias
dc.subject.unesco23 Química
dc.titleTargeting strategies for improving the efficacy of nanomedicine in oncology
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication13785694-551d-4e51-90ca-f777965d8413
relation.isAuthorOfPublication.latestForDiscovery13785694-551d-4e51-90ca-f777965d8413
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