Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population

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dc.contributor.authorFernández Vigo, José Ignacio
dc.contributor.authorGarcía Feijoo, Julián
dc.contributor.authorMartínez De La Casa Fernández-Borrella, José María
dc.contributor.authorGarcía Bella, Javier
dc.contributor.authorArriola Villalobos, Pedro
dc.contributor.authorFernández Pérez, Cristina
dc.contributor.authorFernández Vigo, José Ángel
dc.date.accessioned2023-06-18T05:49:22Z
dc.date.available2023-06-18T05:49:22Z
dc.date.issued2016-04
dc.descriptionRevista en O.A.
dc.description.abstractBackground: Recently, novel anatomic parameters that can be measured by optical coherence tomography (OCT), have been identified as a more objective and accurate method of defining the iridocorneal angle. The aim of the present study is to measure the iridocorneal angle by Fourier domain (FD) OCT and to identify correlations between angle measurements and subject factors in a large healthy Caucasian population. Methods: A cross sectional study was performed in 989 left eyes of 989 healthy subjects. The iridocorneal angle measurements: trabecular-iris angle (TIA), angle opening distance (AOD500) and trabecular-iris space area (TISA500) 500 μm from the scleral spur, were made using the FD-OCT RTVue®. Iris thickness was also measured. Correlations were examined between angle measurements and demographic and ocular factors. The main determinants of angle width were identified by multivariate linear regression. Results: TIA could be measured in 94 % of the eyes, and AOD500 and TISA500 in 92 %. The means recorded were TIA 35.8 ± 12.2 degrees (range 1.5 to 76.1), AOD500 542.6 ± 285.4 μm (range 15 to 1755), and TISA500 0.195 ± 0.104 mm2 (range 0.02 to 0.62). The correlation between the temporal and nasal quadrant was R = 0.902 for TIA. The reproducibility of measurements was excellent (intraclass correlation coefficient >0.947). Mean angle width measurements were smaller in women (p = 0.02). Correlation was detected between angle means and anterior chamber volume (ACV; R = 0.848), anterior chamber depth (ACD; R = 0.818), spherical error (R = -0.619) and age (R = -0.487), while no correlation was observed with Intraocular pressure (R = -0.052). ACV emerged as the main determinant of TIA (R2 = 0.705; p < 0.001). Conclusions: In this Caucasian population, strong correlation was detected between FD-OCT anterior angle measurements and ACV, ACD, spherical refractive error and sex, emerging the ACV as the main determinant of TIA.en
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/44478
dc.identifier.citationFernández Vigo, J. I., García Feijoo, J., Martínez De La Casa Fernández-Borrella, J. M. et al. «Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population». BMC Ophthalmology, vol. 16, n.o 1, abril de 2016, p. 42. BioMed Central, https://doi.org/10.1186/s12886-016-0219-z.
dc.identifier.doi10.1186/s12886-016-0219-z
dc.identifier.issn1471-2415
dc.identifier.officialurlhttps://dx.doi.org/10.1186%2Fs12886-016-0219-z
dc.identifier.relatedurlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835848/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/23416
dc.issue.number42
dc.journal.titleBMC Ophthalmology
dc.language.isoeng
dc.page.total7
dc.publisherBioMed Central
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu617.7-073.75
dc.subject.cdu617.7-007.681
dc.subject.cdu617.71/.72
dc.subject.keywordAnterior chamber
dc.subject.keywordIridocorneal angle
dc.subject.keywordGlaucoma
dc.subject.keywordOptical coherence tomography
dc.subject.ucmOftalmología
dc.subject.ucmTécnicas de la imagen
dc.subject.unesco3201.09 Oftalmología
dc.titleFourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian populationen
dc.typejournal article
dc.volume.number16
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery558b8023-6d72-4dff-9f99-2e60f6f31843
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