Evaluation of the sensitivity and specificity of bovine tuberculosis diagnostic tests in naturally infected cattle herds using a Bayesian approach

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dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorPerez, Andrés
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorMarqués, Sergio
dc.contributor.authorGrau, Anna
dc.contributor.authorSaez, Jose Luis
dc.contributor.authorMínguez, Olga
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.date.accessioned2024-01-16T16:19:19Z
dc.date.available2024-01-16T16:19:19Z
dc.date.issued2012-02-24
dc.description2011 Elsevier B.V. All rights reserved. Financiación: Funded by European Project 212414 ‘‘Strategies for the eradication of bovine tuberculosis (TBSTEP)’’. Julio Alvarez is the recipient of a post-doctoral grant of the University of Castilla la Mancha (UCLM).
dc.description.abstractTest-and-slaughter strategies have been the basis of bovine tuberculosis (BT) eradication programs worldwide; however, eradication efforts have not succeeded in certain regions, and imperfect sensitivity and specificity of applied diagnostic techniques have been deemed as one of the possible causes for such failure. Evaluation of tuberculosis diagnostic tools has been impaired by the lack of an adequate gold standard to define positive and negative individuals. Here, a Bayesian approach was formulated to estimate for the first time sensitivity (Se) and specificity (Sp) of the tests [single intradermal tuberculin (SIT) test, and interferon-gamma (IFN-γ) assay] currently used in Spain. Field data from the first implementation of IFN-γ assay (used in parallel with SIT test 2-6months after a first disclosure SIT test) in infected beef, dairy and bullfighting cattle herds from the region of Castilla and Leon were used for the analysis. Model results suggested that in the described situation: (i) Se of SIT test was highly variable (40.1-92.2% for severe interpretation, median=66-69%), and its Sp was high (>99%) regardless interpretation criteria; (ii) IFN-γ assay showed a high Se (median=89-90% and 83.5% for 0.05 and 0.1 cut-off points respectively) and an acceptable Sp (85.7% and 90.3% for 0.05 and 0.1 thresholds) and (iii) parallel application of both tests maximized the combined Se (95.6% using severe SIT and 0.05 cut-off point in the IFN-γ assay). These results support the potential use of the IFN-γ assay as an ancillary technique for routine BT diagnosis.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Union. European Project 212414 ‘‘Strategies for the eradication of bovine tuberculosis (TBSTEP)’
dc.description.sponsorshipUniversidad de Castilla-La Mancha
dc.description.statuspub
dc.identifier.citationAlvarez, J., Perez, A., Bezos, J., Marqués, S., Grau, A., Saez, J. L., Mínguez, O., de Juan, L., & Domínguez, L. (2012). Evaluation of the sensitivity and specificity of bovine tuberculosis diagnostic tests in naturally infected cattle herds using a Bayesian approach. Veterinary microbiology, 155(1), 38–43. https://doi.org/10.1016/j.vetmic.2011.07.034
dc.identifier.doi10.1016/j.vetmic.2011.07.034
dc.identifier.essn1873-2542
dc.identifier.issn0378-1135
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0378113511004305
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93439
dc.issue.number1
dc.journal.titleVeterinary Microbiology
dc.language.isoeng
dc.page.final43
dc.page.initial38
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579.62
dc.subject.keywordTuberculosis
dc.subject.keywordCattle
dc.subject.keywordSkin testnosis
dc.subject.keywordDiagnosis
dc.subject.keywordInterferon-gamma
dc.subject.keywordBayesian modeling
dc.subject.ucmMicrobiología (Veterinaria)
dc.subject.unesco3109.05 Microbiología
dc.titleEvaluation of the sensitivity and specificity of bovine tuberculosis diagnostic tests in naturally infected cattle herds using a Bayesian approach
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number155
dspace.entity.typePublication
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