Publication:
The neuroprotective actions of oestradiol and oestrogen receptors

dc.contributor.authorArévalo, María Ángeles
dc.contributor.authorAzcoitia Elías, Iñigo
dc.contributor.authorGarcía Segura, Luis Miguel
dc.date.accessioned2023-06-19T15:08:19Z
dc.date.available2023-06-19T15:08:19Z
dc.date.issued2015-01
dc.description.abstractHormones regulate homeostasis by communicating through the bloodstream to the body’s organs, including the brain. As homeostatic regulators of brain function, some hormones exert neuroprotective actions. This is the case for the ovarian hormone 17β‑oestradiol, which signals through oestrogen receptors (ERs) that are widely distributed in the male and female brain. Recent discoveries have shown that oestradiol is not only a reproductive hormone but also a brain-derived neuroprotective factor in males and females and that ERs coordinate multiple signalling mechanisms that protect the brain from neurodegenerative diseases, affective disorders and cognitive decline.
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/41772
dc.identifier.doi10.1038/nrn3856
dc.identifier.issn1471-003X
dc.identifier.officialurlhttp://www.nature.com/nrn/index.html
dc.identifier.urihttps://hdl.handle.net/20.500.14352/35412
dc.journal.titleNature Reviews Neuroscience
dc.language.isoeng
dc.page.final29
dc.page.initial17
dc.publisherMacmillan Publishers
dc.relation.projectIDBFU2011‑30217‑C03‑01
dc.rights.accessRightsrestricted access
dc.subject.cdu576
dc.subject.cdu612.433
dc.subject.keywordBiología Celular
dc.subject.keywordHormonas
dc.subject.keyword17β‑oestradiol
dc.subject.keywordCitología
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2407 Biología Celular
dc.titleThe neuroprotective actions of oestradiol and oestrogen receptors
dc.typejournal article
dc.volume.number16
dspace.entity.typePublication
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