Activity of lactic acid bacteria against biofilms formed by Staphylococcus aureus strains involved in acute mastitis

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dc.contributor.authorJurado Escobar, Rubén
dc.contributor.authorJara Pérez, Josué
dc.contributor.authorAragón, Alberto
dc.contributor.authorHernando, Natalia
dc.contributor.authorRodríguez Gómez, Juan Miguel
dc.contributor.authorFernández Álvarez, Leonides
dc.contributor.authorOrgaz Martín, Belén
dc.date.accessioned2025-12-02T16:30:58Z
dc.date.available2025-12-02T16:30:58Z
dc.date.issued2025
dc.descriptionAuthor contributions RJ conducted the main experiments, performed the data analysis and the figure layout and wrote the original draft; JJ performed some of the experiments and contributed to the data analysis; AA and NH contributed to the data analysis; JMR wrote and reviewed the manuscript; LF and BO designed and supervised the work and wrote and reviewed the manuscript
dc.description.abstractStaphylococcus aureus is the leading cause of acute mastitis during lactation. This species has a remarkable ability to form biofilms and to develop antibiotic resistance, which hampers the effectiveness of current therapeutic approaches. This study aims to evaluate the therapeutic potential of three lactic acid bacteria (LAB) strains (Limosilactobacillus fermentum I7, Limosilactobacillus reuteri 7SNG3-30 and Ligilactobacillus salivarius 22SNG3-30) to interfere with biofilms formed by two S. aureus strains isolated from milk of women with acute mastitis. Both live LAB cells and their respective cell-free supernatants were able to disrupt the S. aureus biofilm structure and significantly reduce its cellular viability. However, the effectiveness of these treatments was dependent on the S. aureus strain, the LAB strain, and the type of LAB preparation (active culture or cell-free supernatant) involved in each interaction. Overall, our results suggest that the tested LAB strains have the potential to be used either as probiotics or postbiotics complementing the current therapies against acute mastitis and other staphylococcal infections
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.departmentDepto. de Farmacia Galénica y Tecnología Alimentaria
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipMinisterio de Educación, Formación Profesional y Deportes (España)
dc.description.statuspub
dc.identifier.citationJurado, R., Jara, J., Aragón, A., Hernando, N., Rodríguez, J. M., Fernández, L., & Orgaz, B. (2025). Activity of lactic acid bacteria against biofilms formed by Staphylococcus aureus strains involved in acute mastitis. Scientific reports, 15(1), 39980. https://doi.org/10.1038/s41598-025-23671-y
dc.identifier.doi10.1038/s41598-025-23671-y
dc.identifier.essn2045-2322
dc.identifier.officialurlhttps://doi.org/10.1038/s41598-025-23671-y
dc.identifier.pmid41238680
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/41238680/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/128353
dc.issue.number39980
dc.journal.titleScientific Reports
dc.language.isoeng
dc.page.final12
dc.page.initial1
dc.publisherNature Research
dc.relation.projectIDPID2022-139262OB-I00
dc.relation.projectIDPRE2020-096035
dc.relation.projectIDPRE2022-CT62/23
dc.relation.projectIDFPU21/04362.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu612.39
dc.subject.keywordStaphylococcus aureus
dc.subject.keywordHuman milk
dc.subject.keywordMastitis
dc.subject.keywordBiofilms
dc.subject.keywordLigilactobacillus salivarius
dc.subject.keywordLimosilactobacillus fermentum
dc.subject.keywordLimosilactobacillus reuteri,
dc.subject.keywordProbiotics
dc.subject.keywordPostbiotics
dc.subject.ucmDietética y nutrición (Medicina)
dc.subject.unesco3109.06 Nutrición
dc.titleActivity of lactic acid bacteria against biofilms formed by Staphylococcus aureus strains involved in acute mastitis
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15(1)
dspace.entity.typePublication
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