Heterobimetallic Catalysis: Platinum‐Gold‐Catalyzed Tandem Cyclization/C−X Coupling Reaction of (Hetero)Arylallenes with Nucleophiles

Alonso Gómez, José Miguel; Muñoz, Maria Paz

Heterobimetallic Catalysis: Platinum‐Gold‐Catalyzed Tandem Cyclization/C−X Coupling Reaction of (Hetero)Arylallenes with Nucleophiles

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Official URL

https://doi.org/10.1002/anie.201800670

Publication date

2018

Authors

Alonso Gómez, José Miguel

Muñoz, Maria Paz

Publisher

Wiley

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URI

https://hdl.handle.net/20.500.14352/92595

Citation

Alonso, J. M.; Muñoz, M. P. Heterobimetallic Catalysis: Platinum-Gold-Catalyzed Tandem Cyclization/C−X Coupling Reaction of (Hetero)Arylallenes with Nucleophiles. Angew. Chem. Int. Ed. 2018, 57, 4742-4746 DOI:10.1002/anie.201800670.

Abstract

Heterobimetallic catalysis offers new opportunities for reactivity and selectivity but still presents challenges, and only a few metal combinations have been explored so far. Reported here is a Pt‐Au heterobimetallic catalyst system for the synthesis of a family of multi‐heteroaromatic structures through tandem cyclization/C−X coupling reaction. Au‐catalyzed 6‐cyclization takes place as the first fast step. Pt‐Au clusters are proposed to be responsible for the increased reactivity in the second step, that is, the intermolecular nucleophilic addition which occurs through an outer‐sphere mechanism by hybrid homogeneous‐heterogeneous catalysis.