Influence of fluid dynamic conditions on 1,3-propanediol production from glycerol by Shimwellia blattae: Carbon flux and cell response

Abstract

The fluid dynamic conditions play a key role in the development and scaling up of bioprocesses. In aerobic cultures, oxygen is an essential substrate for microbial growth, production and culture maintenance; an effective gas-liquid transfer must be achieved. Changes in fluid dynamics due to stirrer speed can affect negatively to the culture, causing hydrodynamic stress (increasing shear stress) or oxidative stress (by an increase of available oxygen in the liquid phase).