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Wernicke’s encephalopathy precipitated by neuromyelitis optica spectrum disorder and Graves’ disease: A tale of clinical and radiological dilemmas

dc.contributor.authorGhosh, Ritwik
dc.contributor.authorDubey, Souvik
dc.contributor.authorRay, Adrija
dc.contributor.authorRoy, Dipayan
dc.contributor.authorDe, Kaustav
dc.contributor.authorMandal, Arpan
dc.contributor.authorNaga, Dinobandhu
dc.contributor.authorSwaika, Bikash Chandra
dc.contributor.authorPandit, Alak
dc.contributor.authorBenito León, Julián
dc.date.accessioned2023-06-16T14:20:01Z
dc.date.available2023-06-16T14:20:01Z
dc.date.issued2021-07-16
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2021)
dc.description.abstractBackground Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathy, may share common clinico-radiological features with Wernicke's encephalopathy (WE). A variant of NMOSD, known as area postrema syndrome (APS), that presents with intractable hiccups and associated vomiting, might lead to the depletion of nutrients if not detected and treated early. Autoimmune thyroid disorders (i.e., Graves’ disease) may be associated with NMOSD. Rarely, thyrotoxicosis can give rise to thiamine depletion and WE. Case presentation Here, we present a case of untreated hyperthyroidism in an Indian female who presented with thyrotoxicosis and later developed WE, possibly also contributed by NMOSD (APS)-induced recurrent vomiting. The patient recovered with antithyroid drugs, parenteral thiamine, and immunomodulatory therapy. The possible pathogenic mechanisms have been discussed. Conclusion Our case establishes the importance of considering NMOSD variants in metabolic encephalopathy, especially if neuroimaging is suggestive and in the backdrop of another autoimmune disorder.en
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/70559
dc.identifier.citationGhosh R, Dubey S, Ray A, Roy D, De K, Mandal A, et al. Wernicke’s encephalopathy precipitated by neuromyelitis optica spectrum disorder and Graves’ disease: A tale of clinical and radiological dilemmas. Clinical & Exp Neuroim 2022;13:67–71. https://doi.org/10.1111/cen3.12661.
dc.identifier.doi10.1111/cen3.12661
dc.identifier.issn1759-1961
dc.identifier.officialurlhttps://doi.org/10.1111/cen3.12661
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4718
dc.journal.titleClinical and Experimental Neuroimmunology
dc.language.isoeng
dc.publisherWiley
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.keywordArea postrema syndrome
dc.subject.keywordAstrocytopathy
dc.subject.keywordNeuromyelitis optica
dc.subject.keywordThyrotoxicosis
dc.subject.keywordWernicke's encephalopathy
dc.subject.ucmMedicina
dc.subject.ucmEndocrinología
dc.subject.ucmInmunología
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3205.02 Endocrinología
dc.subject.unesco2412 Inmunología
dc.subject.unesco2490 Neurociencias
dc.titleWernicke’s encephalopathy precipitated by neuromyelitis optica spectrum disorder and Graves’ disease: A tale of clinical and radiological dilemmasen
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublicationa1c7932c-7b3b-49b4-85f4-99cf7fbbb615
relation.isAuthorOfPublication.latestForDiscoverya1c7932c-7b3b-49b4-85f4-99cf7fbbb615

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