Short-term Effects of Overnight Orthokeratology on Corneal Sub-basal Nerve Plexus Morphology and Corneal Sensitivity

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dc.contributor.authorNombela Palomo, María
dc.contributor.authorFelipe Márquez, Gema
dc.contributor.authorHernández Verdejo, José Luis
dc.contributor.authorNieto Bona, Amelia
dc.date.accessioned2023-06-18T05:49:10Z
dc.date.available2023-06-18T05:49:10Z
dc.date.issued2016-05-26
dc.description.abstractObjective: To assess the effects of a short period of orthokeratology (OK) on corneal subbasal nerve plexus (SBNP) morphology and corneal sensitivity. Methods: Measurements were made in 56 right eyes of 56 subjects with low-to-moderate myopia who wore 2 OK lens designs (Group CRT: HDS 100 Paragon CRT, n=35; Group SF: Seefree; n=21) for a period of 1 month and in 15 right eyes of noncontact lens wearers as controls. The variables determined in each participant were corneal sensitivity using a Cochet-Bonnet esthesiometer and 12 SBNP variables determined on laser scanning confocal microscopy images using 3 different software packages. Correlation between SBNP architecture and corneal sensitivity was also examined. Results: Few changes were observed over the 1-month period in the variables examined in the OK treatment and control groups. However, significant reductions were detected over time in the number of nerves in the central cornea in the groups CRT (P=0.029) and SF (P=0.043) and in central corneal sensitivity in CRT (P=0.047) along with significant increases in central and midperipheral corneal Langerhans cell counts in SF (P=0.001 and 0.048, respectively). Conclusions: This study provides useful data to better understand the anatomical changes induced by OK in corneal SBNP. The different response observed to the 2 OK lens designs requires further investigation.
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/44429
dc.identifier.doi10.1097/ICL.0000000000000282
dc.identifier.issn1542-2321
dc.identifier.officialurlhttp://dx.doi.org/10.1097/ICL.0000000000000282
dc.identifier.relatedurlhttps://www.ncbi.nlm.nih.gov/pubmed/27243354
dc.identifier.urihttps://hdl.handle.net/20.500.14352/23408
dc.journal.titleEye & Contact Lens: Science & Clinical Practice
dc.language.isoeng
dc.page.final8
dc.page.initial1
dc.publisherContact Lens Association of Ophthalmologists, Inc.
dc.rights.accessRightsopen access
dc.subject.cdu617.713-089
dc.subject.cdu681.723
dc.subject.cdu617.713
dc.subject.keywordSubbasal nerve plexus
dc.subject.keywordCorneal sensitivity
dc.subject.keywordOvernight orthokeratology
dc.subject.keywordConfocal microscopy
dc.subject.keywordEsthesiometer
dc.subject.ucmOftalmología
dc.subject.ucmLentes de contacto
dc.subject.ucmOptometría
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco3311.11 Instrumentos ópticos
dc.subject.unesco2209.15 Optometría
dc.titleShort-term Effects of Overnight Orthokeratology on Corneal Sub-basal Nerve Plexus Morphology and Corneal Sensitivity
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication2ed110d3-f335-4688-9c14-1a56e56e8d28
relation.isAuthorOfPublication4f70cc93-25f2-422b-b0e9-8641febc03cb
relation.isAuthorOfPublication.latestForDiscovery2ed110d3-f335-4688-9c14-1a56e56e8d28
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