Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression

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dc.contributor.authorPorras, Néstor
dc.contributor.authorRebollada Merino, Agustín Miguel
dc.contributor.authorRodríguez Franco, Fernando
dc.contributor.authorCalvo-Ibbitson, Andrés
dc.contributor.authorRodríguez Bertos, Antonio Manuel
dc.date.accessioned2024-01-26T13:00:37Z
dc.date.available2024-01-26T13:00:37Z
dc.date.issued2022-06-13
dc.description.abstractFeline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) has been described as an inflammatory disorder with an eosinophilic component with etiopathogenesis that is still unknown. Sixteen intestinal samples from two veterinary diagnostic services (2014–2017) were included in the study. A histopathological criterion classified the cases into three grades (mild, moderate, and severe) according to the distribution of the lesions and the course. An immunohistochemical study of collagen I, collagen III, fibronectin, and transforming growth factor β1 (TGF-β1) was performed in each case. An immunohistochemical study of mild grades shows greater collagen III immunoexpression, compared to collagen I and fibronectin, which suggests an “early” stage of fibrosis. In more intense grades, an increased immunoexpression of collagen I, compared to collagen III, suggests a “late” stage of fibrosis. Otherwise, the highest expression of TGF-β1 was observed in the moderate phase, due to the high proliferation of reactive fibroblast and intense inflammation. The results suggest that the inflammatory infiltrate is the trigger for the elevation in TGF-β1, altering the collagen type III:I ratio. In conclusion, immunohistochemical studies can be a very useful method in diagnosing cases of FGESF of mild grades and could help to apply a differential diagnosis regarding feline eosinophilic chronic enteritis (CEE) in the context of inflammatory bowel disease (IBD).
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.3390/vetsci9060291
dc.identifier.issn2306-7381
dc.identifier.officialurlhttps://www.mdpi.com/2306-7381/9/6/291
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95657
dc.issue.number6
dc.journal.titleVeterinary Sciences
dc.language.isoeng
dc.page.initial291
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordCollagen
dc.subject.keywordFeline gastrointestinal eosinophilic sclerosing fibroplasia
dc.subject.keywordFibronectin
dc.subject.keywordIntestinal fibrosis
dc.subject.keywordImmunohistochemistry
dc.subject.keywordTGF-β1
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmVeterinaria
dc.subject.ucmPatología veterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleFeline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryc3db4ef3-9cd0-47ee-bfc0-ab44a09cde45
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