Gamma band functional connectivity reduction in patients with amnestic mild cognitive impairment and epileptiform activity

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dc.contributor.authorCuesta Prieto, Pablo
dc.contributor.authorOchoa Urrea, Manuela
dc.contributor.authorFunke, Michael
dc.contributor.authorHasan, Omar
dc.contributor.authorZhu, Ping
dc.contributor.authorMarcos Dolado, Alberto
dc.contributor.authorLópez García, María Eugenia
dc.contributor.authorSchulz, Paul E.
dc.contributor.authorLhatoo, Samden
dc.contributor.authorPantazis, Dimitrios
dc.contributor.authorMosher, John C.
dc.contributor.authorMaestu Unturbe, Fernando
dc.date.accessioned2024-02-09T08:24:10Z
dc.date.available2024-02-09T08:24:10Z
dc.date.issued2022-02-03
dc.description.abstractThere is growing evidence for neuronal hyperexcitability in Alzheimer's disease. Hyperexcitability is associated with an increase in epileptiform activity and the disruption of inhibitory activity of interneurons. Interneurons fire at a high rate and are frequently associated with high-frequency oscillations in the gamma frequency band (30-150 Hz). It is unclear how hyperexcitability affects the organization of functional brain networks. A sample of 63 amnestic mild cognitive impairment patients underwent a magnetoencephalography resting-state recording with eyes closed. Twenty (31.75%) mild cognitive impairment patients had epileptiform activity. A cluster-based analysis of the magnetoencephalography functional connectivity revealed a region within the right temporal cortex whose global connectivity in the gamma frequency band was significantly reduced in patients with epileptiform activity relative to those without epileptiform activity. A subsequent seed-based analysis showed that this was largely due to weaker gamma band connectivity of this region with ipsilateral frontal and medial regions, and the upper precuneus area. In addition, this reduced functional connectivity was associated with higher grey matter atrophy across several cortical regions in the patients with epileptiform activity. These functional network disruptions and changes in brain physiology and morphology have important clinical implications as they may contribute to cognitive decline in mild cognitive impairment and Alzheimer's disease.
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipGobierno de España
dc.description.sponsorshipInstitutos Nacionales de Salud
dc.description.statuspub
dc.identifier.citationPablo Cuesta, Manuela Ochoa-Urrea, Michael Funke, Omar Hasan, Ping Zhu, Alberto Marcos, Maria Eugenia López, Paul E. Schulz, Samden Lhatoo, Dimitrios Pantazis, John C. Mosher, Fernando Maestu, Gamma band functional connectivity reduction in patients with amnestic mild cognitive impairment and epileptiform activity, Brain Communications, Volume 4, Issue 2, 2022, fcac012, https://doi.org/10.1093/braincomms/fcac012
dc.identifier.doi10.1093/braincomms/fcac012
dc.identifier.issn2632-1297
dc.identifier.officialurlhttps://academic.oup.com/braincomms/article/4/2/fcac012/6521287
dc.identifier.relatedurlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914494/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100663
dc.issue.number2
dc.journal.titleBrain Communications
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.projectIDPSI2009-14415-C03-01
dc.relation.projectIDPSI2012-38375-C03-01
dc.relation.projectIDRF1AG074204
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612.8
dc.subject.keywordMCI
dc.subject.keywordepileptiform activity
dc.subject.keywordfunctional connectivity
dc.subject.keywordgamma
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2490 Neurociencias
dc.titleGamma band functional connectivity reduction in patients with amnestic mild cognitive impairment and epileptiform activity
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number4
dspace.entity.typePublication
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relation.isAuthorOfPublication542b2457-e80a-4114-ae20-6ca71cd3c79f
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relation.isAuthorOfPublication.latestForDiscovery7070623b-91a0-4590-86f6-227266503c1e
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