Publication:
Genipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications

dc.contributor.authorTacias-Pascacio, Veymar G.
dc.contributor.authorGarcía-Parra, Esmeralda
dc.contributor.authorVela-Gutiérrez, Gilber
dc.contributor.authorVirgen-Ortiz, Jose J.
dc.contributor.authorBerenguer-Murcia, Ángel
dc.contributor.authorAlcántara León, Andrés Rafael
dc.contributor.authorFernandez-Lafuente, Roberto
dc.date.accessioned2023-06-17T09:10:03Z
dc.date.available2023-06-17T09:10:03Z
dc.date.issued2019-12-06
dc.description.abstractGenipin is a reagent isolated from the Gardenia jasminoides fruit extract, and whose low toxicity and good crosslinking properties have converted it into a reactive whose popularity is increasing by the day. These properties have made it widely used in many medical applications, mainly in the production of chitosan materials (crosslinked by this reactive), biological scaffolds for tissue engineering, and nanoparticles of chitosan and nanogels of proteins for controlled drug delivery, the genipin crosslinking being a key point to strengthen the stability of these materials. This review is focused on the mechanism of reaction of this reagent and its use in the design of biocatalysts, where genipin plays a double role, as a support activating agent and as inter- or intramolecular crosslinker. Its low toxicity makes this compound an ideal alterative to glutaraldehyde in these processes. Moreover, in some cases the features of the biocatalysts prepared using genipin surpassed those of the biocatalysts prepared using other standard crosslinkers, even disregarding toxicity. In this way, genipin is a very promising reagent in the design of biocatalysts.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)/FEDER
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipGeneralitat Valenciana
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología (CONACYT) de México
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67101
dc.identifier.doi10.3390/catal9121035
dc.identifier.issn2073-4344
dc.identifier.officialurlhttps://doi.org/10.3390/catal9121035
dc.identifier.relatedurlhttps://www.mdpi.com/2073-4344/9/12/1035
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8313
dc.issue.number12
dc.journal.titleCatalysts
dc.language.isoeng
dc.page.initial1035
dc.publisherMDPI
dc.relation.projectIDRTI2018-095291-B-I00
dc.relation.projectIDCTQ2017-86170-R
dc.relation.projectIDPROMETEOII/2018/076
dc.relation.projectIDCB-2016-01, 286992
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordgenipin
dc.subject.keywordbiocatalyst
dc.subject.keywordinter and intramolecular crosslinking
dc.subject.keywordsupport activation
dc.subject.keywordenzyme immobilization
dc.subject.ucmQuímica farmaceútica
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco2390 Química Farmacéutica
dc.titleGenipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications
dc.typejournal article
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublicationc0d1193e-3161-4c69-af69-830b32f61932
relation.isAuthorOfPublication.latestForDiscoveryc0d1193e-3161-4c69-af69-830b32f61932
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