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Mathematical modeling for protein folding devices. Applications to high pressure processing and microfluidic mixers.

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2010
Authors
Bello Rivas, Juan
Ivorra, Benjamin
López Redondo, Juana
Martínez Ortigosa, Pilar
Ramos del Olmo, Ángel Manuel
Rey Cabezas, Jose María
Smith, Nadia A. S
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Associação Portuguesa de Mecânica Teórica, Aplicada e Computacional
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In this paper, we consider two particular devices used for protein folding. The first one is a microfluidic mixer that perform a folding process by mixing a protein solution with a solvent. We are interested in minimizing its mixing time by choosing suitable shape and flow conditions. The second one is related to food processing and we focus on the modeling and simulation of the temperature evolution inside a high pressure food treatment device. Some of the effects of such treatments is to unfold, and thus inactivate, certain enzymes inside the food sample. The behavior and stability of the proposed model is checked by numerical examples. Furthermore, a simplified version of this model is presented and compared in terms of accuracy and computational time.
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EngOpt 2010 (2nd International Conference On Engineering Optimization. Lisbon, 6-9 September 2010)
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