Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position

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dc.contributor.authorPrieto Montero, Ruth
dc.contributor.authorPrieto Castañeda, Alejandro
dc.contributor.authorKatsumiti, Alberto
dc.contributor.authorSola Llano, Rebeca
dc.contributor.authorRodríguez Agarrabeitia, Antonia
dc.contributor.authorCajaraville, Miren P.
dc.contributor.authorOrtiz García, María Josefa
dc.contributor.authorMartínez Martínez, Virginia
dc.dateReceived 31 July 2021; Received in revised form 2 November 2021; Accepted 3 December 2021
dc.date.accessioned2023-06-16T14:18:21Z
dc.date.available2023-06-16T14:18:21Z
dc.date.issued2021-12-04
dc.description.abstractThree different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (ΦΔ≥0.40) and fluorescence (Φfl≥0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT.en
dc.description.departmentSección Deptal. de Química Orgánica (Óptica y Optometría)
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipGobierno Vasco
dc.description.sponsorshipUniversidad del País Vasco
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/69355
dc.identifier.citationPrieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Red haloBODIPYs as Theragnostic Agents: The Role of the Substitution at Meso Position». Dyes and Pigments, vol. 198, febrero de 2022, p. 110015. DOI.org (Crossref), https://doi.org/10.1016/j.dyepig.2021.110015.
dc.identifier.doi10.1016/j.dyepig.2021.110015
dc.identifier.issn0143-7208
dc.identifier.officialurlhttps://doi.org/10.1016/j.dyepig.2021.110015
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4603
dc.journal.titleDyes and Pigments
dc.language.isoeng
dc.page.initial10 p.
dc.publisherElsevier
dc.relation.projectIDMAT(2017-83856-C3-2-P y 3-P), PID(2020-114347RB-C32), PID(2020-114755 GB-C32)
dc.relation.projectIDIT(912-16), IT(-1302-19) y IT(1639-22)
dc.relation.projectIDCOLAB(19 / 01.)
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu547.1:615.8
dc.subject.cdu543.426
dc.subject.cdu615.8
dc.subject.keywordBODIPY photosensitizer
dc.subject.keywordSinglet oxygen
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordHeLa cells
dc.subject.keywordTheragnosis
dc.subject.ucmQuímica física (Física)
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2210 Química Física
dc.subject.unesco2306 Química Orgánica
dc.titleRed haloBODIPYs as theragnostic agents: The role of the substitution at meso positionen
dc.typejournal article
dc.volume.number198
dspace.entity.typePublication
relation.isAuthorOfPublicationbee889c2-938d-48d9-8748-01e3c8bf5614
relation.isAuthorOfPublication0486160c-3df6-4270-bf91-3e96cd33d85d
relation.isAuthorOfPublication07f337af-8a30-4929-81db-4e92176e5c87
relation.isAuthorOfPublication.latestForDiscoverybee889c2-938d-48d9-8748-01e3c8bf5614
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