BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis
dc.contributor.author | Tabero, Andrea | |
dc.contributor.author | García-Garrido, Fernando | |
dc.contributor.author | Prieto Castañeda, Alejandro | |
dc.contributor.author | Palao, Eduardo | |
dc.contributor.author | Rodríguez Agarrabeitia, Antonia | |
dc.contributor.author | García-Moreno, Inmaculada | |
dc.contributor.author | Villanueva Valdés, Miguel Ángel | |
dc.contributor.author | Moya Cerero, Santiago De La | |
dc.contributor.author | Ortiz, María José | |
dc.date.accessioned | 2024-01-08T13:48:42Z | |
dc.date.available | 2024-01-08T13:48:42Z | |
dc.date.issued | 2019-12-11 | |
dc.description.abstract | Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy. | en |
dc.description.department | Depto. de Química Orgánica | |
dc.description.faculty | Fac. de Óptica y Optometría | |
dc.description.faculty | Fac. de Ciencias Químicas | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.identifier.citation | Tabero, A.; García-Garrido, F.; Prieto-Castañeda, A.; Palao, E.; Agarrabeitia, A. R.; García-Moreno, I.; Villanueva, A.; De la Moya, S., Chem. Commun., 2020, 56, 940-943 | |
dc.identifier.doi | 10.1039/c9cc09397d | |
dc.identifier.officialurl | https://doi.org/10.1039/c9cc09397d | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/91823 | |
dc.journal.title | Chemical Communications | |
dc.language.iso | eng | |
dc.page.final | 943 | |
dc.page.initial | 940 | |
dc.publisher | Royal Society of Chemistry | |
dc.relation.projectID | MINECO (CTQ2016-78454-C2-2-R) | |
dc.relation.projectID | MINECO (MAT2017-83856-C3-1-P) | |
dc.relation.projectID | MINECO (MAT2017-83856-C3-2-P) | |
dc.relation.projectID | Comunidad de Madrid (S2013/MIT-2850) | |
dc.rights.accessRights | restricted access | |
dc.subject.cdu | 547 | |
dc.subject.keyword | BODIPY | |
dc.subject.keyword | Lipid Droplets | |
dc.subject.keyword | Theragnosis Photodynamic | |
dc.subject.ucm | Química orgánica (Química) | |
dc.subject.ucm | Biología celular (Biología) | |
dc.subject.unesco | 2306 Química Orgánica | |
dc.subject.unesco | 2407 Biología Celular | |
dc.title | BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis | en |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 56 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | bee889c2-938d-48d9-8748-01e3c8bf5614 | |
relation.isAuthorOfPublication | 0486160c-3df6-4270-bf91-3e96cd33d85d | |
relation.isAuthorOfPublication | de7d1deb-770b-4c3d-b5bd-d3e72df32296 | |
relation.isAuthorOfPublication | 7940c6e8-25c3-4083-b533-0c34e155dfa8 | |
relation.isAuthorOfPublication.latestForDiscovery | 7940c6e8-25c3-4083-b533-0c34e155dfa8 |
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