BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis

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dc.contributor.authorTabero, Andrea
dc.contributor.authorGarcía-Garrido, Fernando
dc.contributor.authorPrieto Castañeda, Alejandro
dc.contributor.authorPalao, Eduardo
dc.contributor.authorRodríguez Agarrabeitia, Antonia
dc.contributor.authorGarcía-Moreno, Inmaculada
dc.contributor.authorVillanueva Valdés, Miguel Ángel
dc.contributor.authorMoya Cerero, Santiago De La
dc.contributor.authorOrtiz, María José
dc.date.accessioned2024-01-08T13:48:42Z
dc.date.available2024-01-08T13:48:42Z
dc.date.issued2019-12-11
dc.description.abstractEndowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy.en
dc.description.departmentDepto. de Química Orgánica
dc.description.facultyFac. de Óptica y Optometría
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationTabero, A.; García-Garrido, F.; Prieto-Castañeda, A.; Palao, E.; Agarrabeitia, A. R.; García-Moreno, I.; Villanueva, A.; De la Moya, S., Chem. Commun., 2020, 56, 940-943
dc.identifier.doi10.1039/c9cc09397d
dc.identifier.officialurlhttps://doi.org/10.1039/c9cc09397d
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91823
dc.journal.titleChemical Communications
dc.language.isoeng
dc.page.final943
dc.page.initial940
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDMINECO (CTQ2016-78454-C2-2-R)
dc.relation.projectIDMINECO (MAT2017-83856-C3-1-P)
dc.relation.projectIDMINECO (MAT2017-83856-C3-2-P)
dc.relation.projectIDComunidad de Madrid (S2013/MIT-2850)
dc.rights.accessRightsrestricted access
dc.subject.cdu547
dc.subject.keywordBODIPY
dc.subject.keywordLipid Droplets
dc.subject.keywordTheragnosis Photodynamic
dc.subject.ucmQuímica orgánica (Química)
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2306 Química Orgánica
dc.subject.unesco2407 Biología Celular
dc.titleBODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosisen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number56
dspace.entity.typePublication
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relation.isAuthorOfPublication0486160c-3df6-4270-bf91-3e96cd33d85d
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relation.isAuthorOfPublication7940c6e8-25c3-4083-b533-0c34e155dfa8
relation.isAuthorOfPublication.latestForDiscovery7940c6e8-25c3-4083-b533-0c34e155dfa8
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