Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection

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dc.contributor.authorMukhopadhyay, Debanjan
dc.contributor.authorArranz Solís, David
dc.contributor.authorSaeij, Jeroen P. J.
dc.date.accessioned2025-12-18T18:15:02Z
dc.date.available2025-12-18T18:15:02Z
dc.date.issued2020
dc.descriptionAuthor Contributions DM, DA-S, and JPJS have contributed to the conceptualization, writing, and editing of this manuscript. All authors contributed to the article and approved the submitted version
dc.description.abstractToxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on Toxoplasma-induced ileitis and encephalitis.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipAmerican Heart Association Post-doctoral fellowship
dc.description.statuspub
dc.identifier.citationMukhopadhyay, D., Arranz-Solís, D., & Saeij, J. P. J. (2020). Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection. Frontiers in cellular and infection microbiology, 10, 580425. https://doi.org/10.3389/fcimb.2020.580425
dc.identifier.doi10.3389/fcimb.2020.580425
dc.identifier.essn2235-2988
dc.identifier.officialurlhttps://doi.org/10.3389/fcimb.2020.580425
dc.identifier.pmid33178630
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33178630/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/129374
dc.journal.titleFrontiers in Cellular and Infection Microbiology
dc.language.isoeng
dc.page.final22
dc.page.initial1
dc.publisherFrontiers
dc.relation.projectIDR01-AI080621
dc.relation.projectID18POST34030036
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu576.8
dc.subject.keywordToxoplasma
dc.subject.keywordImmune response
dc.subject.keywordStrain
dc.subject.keywordVirulence factor
dc.subject.keywordIleitis
dc.subject.keywordEncephalitis
dc.subject.ucmParasitología (Veterinaria)
dc.subject.ucmParasitología (Medicina)
dc.subject.ucmInmunología
dc.subject.unesco3207.12-1 Parasitología Molecular
dc.titleInfluence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication328dcb1f-f28d-4113-a31d-6348edcd47ed
relation.isAuthorOfPublication.latestForDiscovery328dcb1f-f28d-4113-a31d-6348edcd47ed

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