HLA‐G: Function, polymorphisms and pathology

Suarez‐Trujillo, Fabio; López‐Nares, Adrián; Vaquero, Christian; Palacio‐Gruber, Jose; Arnaiz Villena, Antonio; Juárez Martín-Delgado, Ignacio; Martín Villa, José Manuel

HLA‐G: Function, polymorphisms and pathology

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Int J Immunogenetics - 2020 - Arnaiz‐Villena - HLA‐G Function polymorphisms and pathology.pdf (2.38 MB)

Official URL

https://onlinelibrary.wiley.com/doi/10.1111/iji.12513

Publication date

2020

Authors

Suarez‐Trujillo, Fabio

López‐Nares, Adrián

Vaquero, Christian

Palacio‐Gruber, Jose

Arnaiz Villena, Antonio

Juárez Martín-Delgado, Ignacio

Martín Villa, José Manuel

Publisher

Wiley

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URI

https://hdl.handle.net/20.500.14352/98528

Citation

Arnaiz-Villena A, Juarez I, Suarez-Trujillo F, López-Nares A, Vaquero C, Palacio-Gruber J, Martin-Villa JM. HLA-G: Function, polymorphisms and pathology. Int J Immunogenet. 2021 Apr;48(2):172-192. doi: 10.1111/iji.12513. Epub 2020 Oct 1. PMID: 33001562.

Abstract

HLA-G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA-G function, polymorphism and pathology that have been confirmed by several different researchers, together with exposing aspects that may have been overlooked or not sufficiently remarked in this productive field of study. On the other hand, we question whether performing mainly studies on HLA-G and disease associations is going to give a clear answer in the future, since 40 years of study of classical HLA molecules association with disease has still given no definite answer on this issue.