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Chemical Characterization, Antioxidant Capacity and Anti-Oxidative Stress Potential of South American Fabaceae Desmodium tortuosum

dc.contributor.authorRodríguez, José Luis
dc.contributor.authorBerrios, Paola
dc.contributor.authorClavo, Zoyla-Mirella
dc.contributor.authorMartín-Bravo, Manuel
dc.contributor.authorInostroza-Ruiz, Luis
dc.contributor.authorRamos-González, Mariella
dc.contributor.authorQuispe-Solano, Miguel
dc.contributor.authorFernández Alfonso, María Soledad
dc.contributor.authorPalomino Ruiz-Poveda, Olga María
dc.contributor.authorGoya, Luis
dc.date.accessioned2024-04-26T15:18:26Z
dc.date.available2024-04-26T15:18:26Z
dc.date.issued2023-02-01
dc.description.abstractIt has been proposed that oxidative stress is a pathogenic mechanism to induce cytotoxicity and to cause cardiovascular and neuronal diseases. At present, natural compounds such as plant extracts have been used to reduce the cytotoxic effects produced by agents that induce oxidative stress. Our study aimed to evaluate the antioxidant and cytoprotective capacity of Desmodium tortuosum (D. tortuosum) extract in the co- and pre-treatment in EA.hy926 and SH-SY5Y cell lines subjected to oxidative stress induced by tert-butylhydroperoxide (t-BOOH). Cell viability, reactive oxygen species (ROS), nitric oxide (NO), caspase 3/7 activity, reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), and molecular expression of oxidative stress biomarkers (SOD2, NRF2 and NFκB1) and cell death (APAF1, BAX, Caspase3) were all evaluated. It was observed that the D. tortuosum extract, in a dose-dependent manner, was able to reduce the oxidative and cytotoxicity effects induced by t-BOOH, even normalized to a dose of 200 µg/mL, which would be due to the high content of phenolic compounds mainly phenolic acids, flavonoids, carotenoids and other antioxidant compounds. Finally, these results are indicators that the extract of D. tortuosum could be a natural alternative against the cytotoxic exposure to stressful and cytotoxic chemical agents.
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Nacional Mayor de San Marcos, Lima-Perú
dc.description.statuspub
dc.identifier.citationRodríguez, J. L., Berrios, P., Clavo, Z. M., Marin-Bravo, M., Inostroza-Ruiz, L., Ramos-Gonzalez, M., Quispe-Solano, M., Fernández-Alfonso, M. S., Palomino, O., & Goya, L. (2023). Chemical Characterization, Antioxidant Capacity and Anti-Oxidative Stress Potential of South American Fabaceae Desmodium tortuosum. Nutrients, 15(3), 746. https://doi.org/10.3390/nu15030746
dc.identifier.doi10.3390/nu15030746
dc.identifier.issn2072-6643
dc.identifier.officialurlhttps://doi.org/10.3390/nu15030746
dc.identifier.pmid36771451
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103584
dc.issue.number746
dc.journal.titleNutrients
dc.language.isoeng
dc.page.final20
dc.page.initial1
dc.publisherMDPI
dc.relation.projectIDPCONFIGI A21081221
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615.1
dc.subject.keywordPlant antioxidants
dc.subject.keywordPhytochemicals
dc.subject.keywordPolyphenols
dc.subject.keywordMedicinal plants
dc.subject.keywordVascular endothelium
dc.subject.keywordNeuroprotection
dc.subject.ucmFarmacia
dc.subject.unesco32 Ciencias Médicas
dc.titleChemical Characterization, Antioxidant Capacity and Anti-Oxidative Stress Potential of South American Fabaceae Desmodium tortuosum
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15(3)
dspace.entity.typePublication
relation.isAuthorOfPublication880f080c-4a40-467a-bec8-2dbddbbea997
relation.isAuthorOfPublication55f38dac-c329-406e-830a-ab48763795fb
relation.isAuthorOfPublication.latestForDiscovery880f080c-4a40-467a-bec8-2dbddbbea997

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