The tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?

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dc.contributor.authorLópez Torres, Irene Isabel
dc.contributor.authorVaquero Martín, Francisco Javier
dc.contributor.authorTorres Suárez, Ana Isabel
dc.contributor.authorNavarro García, Federico
dc.contributor.authorFraguas Sánchez, Ana Isabel
dc.contributor.authorLeón Román, Víctor Estuardo
dc.contributor.authorSanz Ruiz, Pablo
dc.date.accessioned2023-06-22T10:40:41Z
dc.date.available2023-06-22T10:40:41Z
dc.date.issued2022-01-06
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2021)
dc.description.abstractPurpose Microencapsulation techniques have allowed the addition of rifampicin to bone cement, but its in vivo efficacy has not been proven. The aim of our study is to determine the superiority of cement containing gentamicin and rifampicin microcapsules in the treatment of PJI versus cement exclusively containing gentamicin. Methods An S. aureus PJI was induced in 15 NZW rabbits. A week after inoculation, the first stage of replacement was carried out, and the animals were divided into two groups: group R received a spacer containing gentamicin and rifampicin microcapsules, and group C received a spacer containing gentamicin. Intra-articular release curve of rifampicin and infection and toxicity markers were monitored for four weeks post-operatively, when microbiological analysis was performed. Results The microbiological cultures showed a significantly lower growth of S. aureus in soft tissue (2.3·104 vs 0; p = 0.01) and bone (5.7·102 vs 0; p = 0.03) in the group with rifampicin microcapsules. No differences were found in systemic toxicity markers. Rifampicin release from the cement spacer showed higher concentrations than the staphylococcal MIC throughout the analysis. Conclusion The in vivo analyses demonstrated the superiority of cement containing gentamicin and rifampicin microcapsules versus the isolated use of gentamicin in the treatment of PJI in the rabbit model without serious side effects due to the systemic absorption of rifampicin. Given the increasing incidence of staphylococci-related PJI, the development of new strategies for intra-articular administration of rifampicin for its treatment has a high clinical impact.en
dc.description.departmentDepto. de Farmacia Galénica y Tecnología Alimentaria
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.departmentDepto. de Cirugía
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid/Banco de Santander
dc.description.sponsorshipMutual Medica scholarships (2017)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/70565
dc.identifier.citationLópez Torres, I. I., Vaquero Martín, F. J., Torres Suárez, A. I. et al. «The Tale of Microencapsulated Rifampicin: Is It Useful for the Treatment of Periprosthetic Joint Infection?» International Orthopaedics, vol. 46, n.o 4, abril de 2022, pp. 677-85. DOI.org (Crossref), https://doi.org/10.1007/s00264-021-05290-0.
dc.identifier.doi10.1007/s00264-021-05290-0
dc.identifier.issn0341-2695
dc.identifier.officialurlhttps://doi.org/10.1007/s00264-021-05290-0
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s00264-021-05290-0
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71323
dc.journal.titleInternational Orthopaedics
dc.language.isoeng
dc.publisherSpringer
dc.relation.projectID(PR26/16–20304, 2016)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordProsthetic joint infection
dc.subject.keywordRifampicin
dc.subject.keywordBone cement
dc.subject.keywordRabbit
dc.subject.ucmReumatología
dc.subject.ucmFarmacología (Farmacia)
dc.subject.unesco3205.09 Reumatología
dc.subject.unesco3209 Farmacología
dc.titleThe tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?en
dc.typejournal article
dspace.entity.typePublication
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