Differential patterns of functional connectivity in Progressive and Stable Mild Cognitive Impairment subjects

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dc.contributor.authorBajo Bretón, Ricardo
dc.contributor.authorCastellanos, Nazareth P.
dc.contributor.authorCuesta Prieto, Pablo
dc.contributor.authorAurtenetxe, Sara
dc.contributor.authorGil Gregorio, Pedro
dc.contributor.authorPozo, Francisco del
dc.contributor.authorMaestu Unturbe, Fernando
dc.date.accessioned2024-02-09T16:22:41Z
dc.date.available2024-02-09T16:22:41Z
dc.date.issued2012-05-10
dc.description.abstractIt is now widely accepted that Alzheimer's disease is characterized by a functional disconnection between brain regions. The disease appears to begin up to decades prior to clinical diagnosis. Therefore, in the present study, we combined magnetoencephalography, a memory task, and functional connectivity analysis in mild cognitive impairment subjects in order to identify functional connectivity patterns that could characterize subjects who would eventually go on to develop the disease. We monitored 19 subjects and finally 5 of them developed Alzheimer's disease. These progressive patients showed a differential profile of functional connectivity values compared with those patients who remained stable over time. Specifically there were higher synchronization values over the parieto-occipital region in α and β frequency bands. The involvement of this brain region in amyloid-β accumulation and its possible association with hyper-synchronization are also discussed.
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationRicardo Bajo, Nazareth P. Castellanos, Pablo Cuesta, Sara Aurtenetxe, Juan Garcia-Prieto, Pedro Gil-Gregorio, Francisco del-Pozo, and Fernando Maestu. Differential Patterns of Connectivity in Progressive Mild Cognitive Impairment. Brain Connectivity.Feb 2012.21-24.
dc.identifier.doi10.1089/brain.2011.0069
dc.identifier.essn2158-0022
dc.identifier.issn2158-0014
dc.identifier.officialurlhttps://www.liebertpub.com/doi/pdf/10.1089/brain.2011.0069?download=true
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/22458376/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101018
dc.issue.number1
dc.journal.titleBrain Connectivity
dc.language.isoeng
dc.page.final24
dc.page.initial21
dc.publisherMary Ann Liebert, Inc.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu612.8
dc.subject.keywordSynchronization likelihood
dc.subject.keywordProgressive mild cognitive impairment
dc.subject.keywordStable mild cognitive impairment,
dc.subject.keywordAlzheimer Disease
dc.subject.keywordMagnetoencephalography
dc.subject.keywordFunctional connectivity
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2490 Neurociencias
dc.titleDifferential patterns of functional connectivity in Progressive and Stable Mild Cognitive Impairment subjects
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number2
dspace.entity.typePublication
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relation.isAuthorOfPublication7070623b-91a0-4590-86f6-227266503c1e
relation.isAuthorOfPublication59b41e19-a468-4ccb-b3a5-f35742d186c4
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relation.isAuthorOfPublication.latestForDiscovery3bc536b8-5f73-41df-a201-114bb6c50591
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