Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma

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dc.contributor.authorDaschner, A.
dc.contributor.authorGonzález Fernández, Juan
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.date.accessioned2024-01-19T12:20:40Z
dc.date.available2024-01-19T12:20:40Z
dc.date.issued2017-05
dc.description.abstractWith the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationGonzález-Fernández J, Daschner A, Cuéllar C. Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma. Allergol Immunopathol (Madr). 2017 May-Jun;45(3):297-304.
dc.identifier.doi10.1016/j.aller.2016.08.002
dc.identifier.issn0301-0546
dc.identifier.officialurlhttps://doi.org/10.1016/j.aller.2016.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94044
dc.issue.number3
dc.journal.titleAllergologia et Immunopathologia
dc.language.isoeng
dc.page.final304
dc.page.initial297
dc.publisherElsevier
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu576.8
dc.subject.keywordCross-reactivity
dc.subject.keywordEvolution
dc.subject.keywordFish
dc.subject.keywordIgE
dc.subject.keywordPanallergen
dc.subject.keywordTropomyosin
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco3207.12 Parasitología
dc.titleAllergenicity of vertebrate tropomyosins: Challenging an immunological dogma
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number45
dspace.entity.typePublication
relation.isAuthorOfPublicationfb07d421-e0c9-4722-83bd-4be5e3901c6d
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication.latestForDiscoveryfb07d421-e0c9-4722-83bd-4be5e3901c6d
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