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Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum

dc.contributor.authorValcárcel Olmeda, Ángela
dc.contributor.authorBriones Montero, Andrea
dc.contributor.authorRodero Martínez, Marta
dc.contributor.authorGonzález Fernández, Juan
dc.contributor.authorOlmeda García, Ángeles Sonia
dc.contributor.authorValcárcel, Félix
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.date.accessioned2024-05-24T14:25:51Z
dc.date.available2024-05-24T14:25:51Z
dc.date.issued2024-05-13
dc.description2024 Acuerdos transformativos CRUE
dc.description.abstractAlpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.
dc.description.departmentDepto. de Sanidad Animal
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Veterinaria
dc.description.facultyFac. de Farmacia
dc.description.fundingtypeAPC financiada por la UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationValcárcel, Á., Montero, A.B., Rodero, M., González-Fernández, J., Olmeda, A.S., Valcárcel, F. et al. (2024) Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum. Medical and Veterinary Entomology, 1–6. Available from: https://doi.org/10.1111/mve.12724
dc.identifier.doi10.1111/mve.12724
dc.identifier.essn1365-2915
dc.identifier.issn0269-283X
dc.identifier.officialurlhttps://doi.org/10.1111/mve.12724
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/38741222/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104412
dc.journal.titleMedical and Veterinary Entomology
dc.language.isoeng
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu576.8
dc.subject.keywordAlpha-Gal epitope
dc.subject.keywordDigestive tract
dc.subject.keywordHyalomma lusitanicum
dc.subject.keywordMediterranean ticks
dc.subject.keywordRed meat allergy
dc.subject.keywordSalivary glands
dc.subject.keywordTick-induced allergy
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco3207.12 Parasitología
dc.titleAlpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.numberEarly view
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery5b09d749-d306-40df-b523-4ab0a479f162

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