Immunologic responses to the major allergen of Olea Europaea in local and systemic allergic rhinitis subjects

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dc.contributor.authorCampo, Paloma
dc.contributor.authorVillalba Díaz, Mayte
dc.contributor.authorBarrionuevo, Esther
dc.contributor.authorRondón, Carmen
dc.contributor.authorGalindo, Luisa
dc.contributor.authorRodríguez, María José
dc.contributor.authorLópez Rodríguez, Juan Carlos
dc.contributor.authorTorres, María José
dc.contributor.authorBlanca, Miguel
dc.contributor.authorMayorga, Cristobalina
dc.date.accessioned2023-06-19T14:56:09Z
dc.date.available2023-06-19T14:56:09Z
dc.date.issued2015
dc.description.abstractEvaluate: the in vivo and in vitro responses to nOle e 1 in allergic rhinitis (AR) and local allergic rhinitis (LAR) patients sensitized to olive tree pollen (OL) confirmed by nasal allergen provocation test (NAPT). Methods: Twelve subjects with AR, 12 with LAR, and 12 subjects as control group (CG) were selected. Skin testing and NAPT with nOle e 1 were performed. ECP and tryptase were measured in nasal lavages before and after NAPT. Serum IgE to OL allergens were measured by ELISA. Basophil activation tests (BAT) with OL and nOle e 1 and dendritic cell maturation/proliferation studies were carried out. Results: All AR (12/12) and 10/12 (83%) of LAR had a +NAPT to nOle e 1. ECP levels in nasal lavages were significantly increased after NAPT in both AR and LAR compared with CG at 15 minutes (p<0.05). Serum IgE was positive only in AR. All AR had +BAT responses to OL and 10/12 to nOle e 1 (83%); 8/12 LAR (66.6%) had a +BAT with OL and 4/12 (33%) to nOle e 1, with only one subject of the control group with a +BAT to both OL and nOle e 1 (8%). Dendritic cell proliferation to nOle e 1 was increased in AR compared to LAR and CG (p=0.019 and p=0.001 respectively).Conclusion: Both AR and LAR had a similar in vivo response to nOle e 1 with release of inflammatory mediators. Specific basophil activation with OL and nOle e 1 was observed in LAR confirming previous data obtained with dust mites.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipSpanish Health Ministry Fund for Health in Spain (FIS)
dc.description.sponsorshipMinistry of Innovation
dc.description.sponsorshipAndalusian Health Ministry
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/33117
dc.identifier.doi10.1111/cea.12600
dc.identifier.issn2045-7022
dc.identifier.officialurlhttp://www.ctajournal.com/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/34857
dc.issue.numbersup.4
dc.journal.titleClinical and Translational Allergy
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.projectIDRIRAAF (RD07/0064) and RD12/0013/0015
dc.relation.projectIDFIS PI11/02619 and PI12/00900
dc.relation.projectIDPI-0542-2010 and CTS-7433
dc.rights.accessRightsopen access
dc.subject.cdu577.1
dc.subject.cdu616-056.3
dc.subject.keywordBasophil activation test
dc.subject.keywordlocal allergic rhinitis
dc.subject.keywordnasal allergen provocation test
dc.subject.keywordpurified allergen
dc.subject.ucmAlergología
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco3207.01 Alergias
dc.subject.unesco2302 Bioquímica
dc.titleImmunologic responses to the major allergen of Olea Europaea in local and systemic allergic rhinitis subjects
dc.typejournal article
dc.volume.number5
dspace.entity.typePublication
relation.isAuthorOfPublicationb9515131-fd92-4e57-923d-84da1d3bc75e
relation.isAuthorOfPublication.latestForDiscoveryb9515131-fd92-4e57-923d-84da1d3bc75e
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