Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
dc.contributor.author | Galve Roperh, Ismael | |
dc.contributor.author | Aguado Sánchez, Tania | |
dc.contributor.author | Rueda, Daniel | |
dc.contributor.author | Velasco Díez, Guillermo | |
dc.contributor.author | Guzmán Pastor, Manuel | |
dc.date.accessioned | 2023-12-14T12:06:52Z | |
dc.date.available | 2023-12-14T12:06:52Z | |
dc.date.issued | 2006-06-01 | |
dc.description.abstract | The endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol are important retrograde messengers that inhibit neurotransmitter release via presynaptic CB1 receptors. In addition, cannabinoids are known to modulate the cell death/survival decision of different neural cell types, leading to different outcomes that depend on the nature of the target cell and its proliferative/differentiation status. Thus, cannabinoids protect primary neurons, astrocytes and oligodendrocytes from apoptosis, whereas transformed glial cells are prone to apoptosis by cannabinoid challenge. Moreover, a potential role of the eCB system in neurogenesis and neural differentiation has been proposed. Recent research shows that eCBs stimulate neural progenitor proliferation and inhibit hippocampal neurogenesis in normal adult brain. Cannabinoids inhibit cortical neuron differentiation and promote glial differentiation. On the other hand, experiments with differentiated neurons have shown that cannabinoids also regulate neuritogenesis, axonal growth and synaptogenesis. These new observations support that eCBs constitute a new family of lipid signaling cues responsible for the regulation of neural progenitor proliferation and differentiation, acting as instructive proliferative signals through the CB1 receptor. | |
dc.description.department | Depto. de Bioquímica y Biología Molecular | |
dc.description.faculty | Fac. de Ciencias Biológicas | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Educación y Ciencia | |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología. Programa Ramón y Cajal | |
dc.description.sponsorship | Comunidad de Madrid | |
dc.description.sponsorship | Fundación Científica de la Asociación Española Contra el Cáncer | |
dc.description.status | pub | |
dc.identifier.doi | 10.2174/138161206777585139 | |
dc.identifier.essn | 1873-4286 | |
dc.identifier.issn | 1381-6128 | |
dc.identifier.officialurl | https://www.eurekaselect.com/article/1214 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/91292 | |
dc.issue.number | 18 | |
dc.journal.title | Current Pharmaceutical Design | |
dc.language.iso | eng | |
dc.page.final | 7 | |
dc.page.initial | 1 | |
dc.publisher | Bentham Science Publishers | |
dc.relation.projectID | (SAF2002-04687 and SAF200300745) | |
dc.relation.projectID | (CM08.5/0010/ 2003) | |
dc.rights.accessRights | restricted access | |
dc.subject.cdu | 615.9 | |
dc.subject.cdu | 577.175.82 | |
dc.subject.keyword | Neurogenesis | |
dc.subject.keyword | Glioprotective action | |
dc.subject.keyword | Synaptogenesis | |
dc.subject.keyword | Cannabinoid receptors | |
dc.subject.keyword | ERK pathway | |
dc.subject.keyword | Neural progenitor differentiation | |
dc.subject.ucm | Bioquímica (Biología) | |
dc.subject.ucm | Neurociencias (Biológicas) | |
dc.subject.unesco | 2403 Bioquímica | |
dc.subject.unesco | 2490 Neurociencias | |
dc.title | Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 12 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 8c2a1d13-f2a3-4355-8b66-73e0f97c0cea | |
relation.isAuthorOfPublication | bde4a39d-9dc8-42b0-9f07-fb332f13c2d6 | |
relation.isAuthorOfPublication | 4a33b5e2-6540-4927-ab0d-bc37f5cd8b5b | |
relation.isAuthorOfPublication | db8f53b8-3d54-4c2f-a483-c307151c09df | |
relation.isAuthorOfPublication.latestForDiscovery | 8c2a1d13-f2a3-4355-8b66-73e0f97c0cea |
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