Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development

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dc.contributor.authorGalve Roperh, Ismael
dc.contributor.authorAguado Sánchez, Tania
dc.contributor.authorRueda, Daniel
dc.contributor.authorVelasco Díez, Guillermo
dc.contributor.authorGuzmán Pastor, Manuel
dc.date.accessioned2023-12-14T12:06:52Z
dc.date.available2023-12-14T12:06:52Z
dc.date.issued2006-06-01
dc.description.abstractThe endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol are important retrograde messengers that inhibit neurotransmitter release via presynaptic CB1 receptors. In addition, cannabinoids are known to modulate the cell death/survival decision of different neural cell types, leading to different outcomes that depend on the nature of the target cell and its proliferative/differentiation status. Thus, cannabinoids protect primary neurons, astrocytes and oligodendrocytes from apoptosis, whereas transformed glial cells are prone to apoptosis by cannabinoid challenge. Moreover, a potential role of the eCB system in neurogenesis and neural differentiation has been proposed. Recent research shows that eCBs stimulate neural progenitor proliferation and inhibit hippocampal neurogenesis in normal adult brain. Cannabinoids inhibit cortical neuron differentiation and promote glial differentiation. On the other hand, experiments with differentiated neurons have shown that cannabinoids also regulate neuritogenesis, axonal growth and synaptogenesis. These new observations support that eCBs constitute a new family of lipid signaling cues responsible for the regulation of neural progenitor proliferation and differentiation, acting as instructive proliferative signals through the CB1 receptor.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Educación y Ciencia
dc.description.sponsorshipMinisterio de Ciencia y Tecnología. Programa Ramón y Cajal
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipFundación Científica de la Asociación Española Contra el Cáncer
dc.description.statuspub
dc.identifier.doi10.2174/138161206777585139
dc.identifier.essn1873-4286
dc.identifier.issn1381-6128
dc.identifier.officialurlhttps://www.eurekaselect.com/article/1214
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91292
dc.issue.number18
dc.journal.titleCurrent Pharmaceutical Design
dc.language.isoeng
dc.page.final7
dc.page.initial1
dc.publisherBentham Science Publishers
dc.relation.projectID(SAF2002-04687 and SAF200300745)
dc.relation.projectID(CM08.5/0010/ 2003)
dc.rights.accessRightsrestricted access
dc.subject.cdu615.9
dc.subject.cdu577.175.82
dc.subject.keywordNeurogenesis
dc.subject.keywordGlioprotective action
dc.subject.keywordSynaptogenesis
dc.subject.keywordCannabinoid receptors
dc.subject.keywordERK pathway
dc.subject.keywordNeural progenitor differentiation
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2490 Neurociencias
dc.titleEndocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
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