Investigation on the relationship between lipid composition and structure in model membranes composed of extracted natural phospholipids

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dc.contributor.authorSantamaria, Andreas
dc.contributor.authorBatchu, Krishna
dc.contributor.authorFragneto, Giovanna
dc.contributor.authorLaux, Valérie
dc.contributor.authorHaertlein, Michael
dc.contributor.authorDarwish, Tamim
dc.contributor.authorRussell, Robert
dc.contributor.authorZaccai, Nathan
dc.contributor.authorGuzmán Solís, Eduardo
dc.contributor.authorMaestro, Armando
dc.date.accessioned2024-01-24T15:50:01Z
dc.date.available2024-01-24T15:50:01Z
dc.date.issued2023
dc.description.abstractHypothesis Unravelling the structural diversity of cellular membranes is a paramount challenge in life sciences. In particular, lipid composition affects the membrane collective behaviour, and its interactions with other biological molecules. Experiments Here, the relationship between membrane composition and resultant structural features was investigated by surface pressure-area isotherms, Brewster angle microscopy and neutron reflectometry on in vitro membrane models of the mammalian plasma and endoplasmic-reticulum-Golgi intermediate compartment membranes in the form of Langmuir monolayers. Natural extracted yeast lipids were used because, unlike synthetic lipids, the acyl chain saturation pattern of yeast and mammalian lipids are similar. Findings The structure of the model membranes, orthogonal to the plane of the membrane, as well as their lateral packing, were found to depend strongly on their specific composition, with cholesterol having a major influence on the in-plane morphology, yielding a coexistence of liquid-order and liquid-disorder phases.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.facultyInstituto Pluridisciplinar (IP)
dc.description.refereedTRUE
dc.description.sponsorshipEusko Jaurlaritza
dc.description.sponsorshipThe National Collaborative Research Infrastructure Strategy (Australia)
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipInstitut Laue-Langevin (Francia)
dc.description.sponsorshipWellcome Trust (Reino Unido)
dc.description.statuspub
dc.identifier.citationSantamaria, Andreas, et al. «Investigation on the Relationship between Lipid Composition and Structure in Model Membranes Composed of Extracted Natural Phospholipids». Journal of Colloid and Interface Science, vol. 637, mayo de 2023, pp. 55-66. https://doi.org/10.1016/j.jcis.2023.01.043.
dc.identifier.doi10.1016/j.jcis.2023.01.043
dc.identifier.issn0021-9797
dc.identifier.officialurlhttps://doi.org/10.1016/j.jcis.2023.01.043
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95186
dc.journal.titleJournal Colloid and Interface Science
dc.language.isoeng
dc.page.final66
dc.page.initial55
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ucmQuímica
dc.subject.unesco2307 Química Física
dc.subject.unesco2210 Química Física
dc.subject.unesco2299 Otras Especialidades Físicas
dc.titleInvestigation on the relationship between lipid composition and structure in model membranes composed of extracted natural phospholipids
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number637
dspace.entity.typePublication
relation.isAuthorOfPublication8461433f-f4e7-40b0-9549-b14c34817028
relation.isAuthorOfPublication.latestForDiscovery8461433f-f4e7-40b0-9549-b14c34817028
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