Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders

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dc.contributor.authorGarcía Marchena, Nuria
dc.contributor.authorMartín Velasco, Ana Isabel
dc.contributor.authorVillanúa Bernués, María Ángeles
dc.contributor.authorRubio Valladolid, Gabriel
dc.contributor.authorPavón Moron, Francisco José
dc.date.accessioned2023-11-22T12:51:37Z
dc.date.available2023-11-22T12:51:37Z
dc.date.issued2017-11-06
dc.description.abstractThe identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3). The association of these plasma peptides with relevant AUD-related variables and psychiatric comorbidity was explored. The alcohol group was diagnosed with severe AUD and showed an average of 13 years of problematic use and 10 months of abstinence at the moment of participating in the study. Regarding common medical conditions associated with AUD, we observed an elevated incidence of alcohol-induced liver and pancreas diseases (18.7%) and psychiatric comorbidity (76.9%). Thus, AUD patients displayed a high prevalence of dual diagnosis (39.3%) [mainly depression (19.9%)] and comorbid substance use disorders (40.7%). Plasma BDNF and IGF-1 concentrations were significantly lower in the alcohol group than in the control group (p<0.001). Remarkably, there was a negative association between IGF-1 concentrations and age in the control group (r = -0.52, p<0.001) that was not found in the alcohol group. Concerning AUD-related variables, AUD patients with liver and pancreas diseases showed even lower concentrations of BDNF (p<0.05). In contrast, the changes in plasma concentrations of these peptides were not associated with abstinence, problematic use, AUD severity or lifetime psychiatric comorbidity. These results suggest that further research is necessary to elucidate the role of BDNF in alcohol-induced toxicity and the biological significance of the lack of correlation between age and plasma IGF-1 levels in abstinent AUD patients.
dc.description.departmentDepto. de Fisiología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipFondos FEDER
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipMinisterio de Sanidad, Servicios Sociales e Igualdad (España)
dc.description.sponsorshipJunta de Andalucía
dc.description.sponsorshipRETICS Red de Trastornos Adictivos
dc.description.statuspub
dc.identifier.citationGarcía-Marchena N, Silva-Peña D, Martín-Velasco AI, Villanúa MÁ, Araos P, Pedraz M, et al. (2017) Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. PLoS ONE 12(11): e0187634. https://doi.org/10.1371/journal.pone.0187634
dc.identifier.doi10.1371/journal.pone.0187634
dc.identifier.essn1932-6203
dc.identifier.officialurlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187634
dc.identifier.urihttps://hdl.handle.net/20.500.14352/88911
dc.issue.number11
dc.journal.titlePlos One
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.projectIDRD16/0017/ 0001
dc.relation.projectIDPI16/ 01698
dc.relation.projectIDPlan Nacional sobre Drogas (PNSD 049/2013)
dc.relation.projectIDPI16/01953
dc.relation.projectIDPI13/02261
dc.relation.projectIDPI16/01953
dc.relation.projectIDPI0228-2013
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612
dc.subject.keywordAlcohol consumption
dc.subject.keywordAlcoholism
dc.subject.keywordBlood plasma
dc.subject.keywordGrowth factors
dc.subject.keywordLiver diseases
dc.subject.keywordPancreas
dc.subject.keywordAlcoholic liver disease
dc.subject.keywordNerve growth factor
dc.subject.ucmFisiología
dc.subject.unesco2411 Fisiología Humana
dc.titleDecreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
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relation.isAuthorOfPublicationa3c1c28c-3409-4c97-9d0a-9ac2e7cd63cc
relation.isAuthorOfPublication025c4607-2d63-4297-8073-0b884d4f8cff
relation.isAuthorOfPublication.latestForDiscoveryf0007aeb-d0d0-40e5-b126-9d924732658b
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