Multivalent antibodies: when design surpasses evolution

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dc.contributor.authorCuesta Martínez, Ángel
dc.contributor.authorSainz-Pastor, Noelia
dc.contributor.authorBonet, Jaume
dc.contributor.authorOliva, Baldomero
dc.contributor.authorÁlvarez-Vallina, Luis
dc.date.accessioned2024-01-12T13:07:48Z
dc.date.available2024-01-12T13:07:48Z
dc.date.issued2010
dc.description.abstractEvolutionary pressure has selected antibodies as key immune molecules acting against foreign pathogens. The development of monoclonal antibody technology has allowed their widespread use in research, real-time diagnosis and treatment of multiple diseases, including cancer. However, compared with hematologic malignancies, solid tumors have often proven to be relatively resistant to antibody-based therapies. In an attempt to improve the tumor-targeting efficacy of antibodies, new formats with modified, multivalent properties have been generated. Initially, these formats imitated the structure of native IgG, creating mostly monospecific, bivalent antibodies. Recently, novel trivalent antibodies have been developed to maximize tumor targeting capabilities through enhanced biodistribution and functional affinity. We review recent advances in the engineering of multivalent antibodies and further discuss their promise as agents for invivo diagnostics and therapy.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationCuesta AM, Sainz-Pastor N, Bonet J, Oliva B, Alvarez-Vallina L. Multivalent antibodies: when design surpasses evolution. Trends Biotechnol. 2010;28(7):355-362. doi:10.1016/j.tibtech.2010.03.007
dc.identifier.doi10.1016/j.tibtech.2010.03.007
dc.identifier.essn1879-3096
dc.identifier.issn0167-7799
dc.identifier.officialurlhttps://doi.org/10.1016/j.tibtech.2010.03.007
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0167779910000557?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92799
dc.issue.number7
dc.journal.titleTrends in Biotechnology
dc.language.isoeng
dc.page.final362
dc.page.initial355
dc.publisherCell Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/BIO2008-03233
dc.relation.projectIDinfo:eu-repo/grantAgreement/Angiobodies-S-BIO-0236-2006
dc.relation.projectIDinfo:eu-repo/grantAgreement/BIO2008-00205
dc.rights.accessRightsrestricted access
dc.subject.cdu612.017
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleMultivalent antibodies: when design surpasses evolution
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number28
dspace.entity.typePublication
relation.isAuthorOfPublication963e050e-5a67-40d7-8e25-3dc7ff5a8619
relation.isAuthorOfPublication.latestForDiscovery963e050e-5a67-40d7-8e25-3dc7ff5a8619
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