Analysis of the Plasma Proteome Associated with Acute Coronary Syndrome: Does a Permanent Protein Signature Exist in the Plasma of ACS Patients?

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dc.contributor.authorDardé, Veronica
dc.contributor.authorCuesta, Fernando de la
dc.contributor.authorGil Dones, Félix
dc.contributor.authorÁlvarez Llamas, Gloria
dc.contributor.authorBarderas, Maria
dc.contributor.authorVivanco Martínez, Fernando
dc.date.accessioned2024-01-23T12:13:06Z
dc.date.available2024-01-23T12:13:06Z
dc.date.issued2010
dc.descriptionThis work was supported by Comunidad de Madrid (Proteomarkers), Fina Biotech, Sociedad Española de Aterosclerosis, FIS (PI-080970), Mutua Madrileña (20174/ 004), Ministerio de Ciencia (BFU-2005,08838)
dc.description.abstractAcute coronary syndrome (ACS) is triggered by the occlusion of a coronary artery usually due to the thrombosis caused by an atherosclerotic plaque. The identification of proteins directly involved in the pathophysiological events underlying ACS will enable more precise diagnoses and a more accurate prognosis to be determined. Accordingly, we have performed a longitudinal study of the plasma proteome in ACS patients by 2-DE and DIGE. Plasma samples from patients, healthy controls, and stable coronary artery disease (CAD) patients were immunodepleted of the six most abundant proteins, and they were analyzed in parallel at four different times: 0 (on admission) and after 4, 60, and 180 days. From a total of 1400 spot proteins analyzed, 33 proteins were differentially expressed in ACS patients when compared with control subjects/stable patients. A small group of seven proteins that appear to be altered at admission remain affected for 6 months and also in the stable CAD patients. Interestingly, the maximum number of altered proteins was observed in the stable CAD patients. Some of the proteins identified had been previously associated with ACS whereas others (such as Alpha-1-B-glycoprotein, Hakata antigen, Tetranectin, Tropomyosin 4) constitute novel proteins that are altered in this pathology.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipFina Biotech
dc.description.sponsorshipSociedad Española de Aterosclerosis
dc.description.sponsorshipMutua Madrileña
dc.description.sponsorshipMinisterio de Ciencia (España)
dc.description.statuspub
dc.identifier.citationDardé, Veronica M., et al. «Analysis of the Plasma Proteome Associated with Acute Coronary Syndrome: Does a Permanent Protein Signature Exist in the Plasma of ACS Patients?» Journal of Proteome Research, vol. 9, n.o 9, septiembre de 2010, pp. 4420-32. https://doi.org/10.1021/pr1002017.
dc.identifier.doi10.1021/pr1002017
dc.identifier.essn1535-3907
dc.identifier.issn1535-3893
dc.identifier.officialurlhttps://doi.org/10.1021/pr1002017
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94732
dc.issue.number9
dc.journal.titleJournal of protemoe research
dc.language.isoeng
dc.page.final4432
dc.page.initial4420
dc.publisherAmerican Chemical Society
dc.rights.accessRightsrestricted access
dc.subject.cdu577.112
dc.subject.cdu577.21
dc.subject.cdu616.12
dc.subject.keywordAcute coronary syndrome
dc.subject.keywordPlasma biomarkers
dc.subject.keywordAtherotrombosis
dc.subject.keywordMyocardial infarction
dc.subject.keywordCoronary artery disease
dc.subject.keywordAtherosclerosis,
dc.subject.keywordProtein signature
dc.subject.keywordDIGE
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmGenética
dc.subject.ucmCardiología
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2409 Genética
dc.subject.unesco3205.01 Cardiología
dc.titleAnalysis of the Plasma Proteome Associated with Acute Coronary Syndrome: Does a Permanent Protein Signature Exist in the Plasma of ACS Patients?
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublication0827e638-921a-4475-9a48-b859587719c5
relation.isAuthorOfPublication16e9b128-f6de-4009-817c-53e91375baa3
relation.isAuthorOfPublication6f3e7679-cbc7-4f23-8355-2de0876d46ad
relation.isAuthorOfPublication.latestForDiscovery0827e638-921a-4475-9a48-b859587719c5
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